Peer-reviewed veterinary case report
How cefovecin and other antibiotics kill dog Staph and E coli bacteria
By Blondeau, Joseph M & Shebelski, Shantelle D·Published in Veterinary dermatology·2016·Royal University Hospital and Saskatoon Health Region, Canada·View original on PubMed →
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Original publication title: Comparative in vitro killing of canine strains of Staphylococcus pseudintermedius and Escherichia coli by cefovecin, cefazolin, doxycycline and pradofloxacin.
- Species:
- dog
Plain-English summary
A study tested how well different antibiotics could kill bacteria that commonly infect dogs, specifically Staphylococcus pseudintermedius and E. coli. The antibiotic pradofloxacin was found to kill these bacteria much faster than cefazolin, cefovecin, or doxycycline. This rapid action could help dogs recover more quickly from skin infections. If your dog has a skin infection, your vet may consider using pradofloxacin for faster results.
People also search for: dog skin infection treatment · pradofloxacin for dogs · antibiotics for dog infections
Abstract
BACKGROUND: Bacterial eradication is necessary for clinical cure of infections and antimicrobial agents are important adjunctive therapies for inhibiting the growth of or killing bacteria. Pre-existing skin diseases predispose animals to infection by Staphylococcus pseudintermedius and, more rarely, by Gram-negative bacilli. The property of rapid killing of bacteria may influence drug selection and duration of therapy in the setting of infection. OBJECTIVES: To test the killing of canine isolates of S. pseudintermedius and Escherichia coli by cefazolin, cefovecin, doxycycline and pradofloxacin at the minimum inhibitory, mutant prevention, maximum serum and maximum tissue drug concentrations. METHODS: Under standard conditions, bacterial cells were exposed to clinically relevant drug concentrations in vitro and the log10 reduction (and % kill) of viable cells measured at 5, 10, 15, 20, 25, 30, 60, 120 and 180 min after drug exposure. RESULTS: Statistically significant differences were seen between killing efficiencies by pradofloxacin versus the other agents, whereby pradofloxacin killed cells more rapidly than the others. For example, against the S. pseudintermedius strains, significantly more cells were killed by pradofloxacin following 15 min of maximum tissue drug concentration exposure than for cefazolin (P = 0.0002), cefovecin (P = 0.0007) and doxycycline (P ≤ 0.0001). CONCLUSION AND CLINICAL IMPORTANCE: The rank order of potency based on these kill experiments was pradofloxacin > cefazolin > cefovecin > doxycycline. Rapid killing of bacteria affects the speed of clinical resolution and may influence drug selection and duration of therapy for skin infections.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27307405/