Peer-reviewed veterinary case report
Nuclear differences in dog basal cell tumors that came back or not
By Simeonov, Radostin & Simeonova, Galina·Published in Veterinary clinical pathology·2010·Department of General and Clinical Pathology of Animals·View original on PubMed →
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Original publication title: Comparative morphometric analysis of recurrent and nonrecurrent canine basal cell carcinomas: a preliminary report.
- Species:
- dog
Plain-English summary
A study looked at 11 dogs with basal cell carcinomas (BCCs), a type of skin tumor, to see if certain cell measurements could help predict if the tumors would come back after being removed. Out of the dogs, 6 had tumors that did not return within 60 weeks, while 5 had tumors that did recur. The researchers found that the cells from the recurrent tumors were larger and had different shapes compared to those from the nonrecurrent tumors. This suggests that measuring these cell characteristics might help vets determine which tumors are more likely to come back after treatment.
People also search for: dog skin tumor recurrence · basal cell carcinoma in dogs · dog tumor treatment options
Abstract
BACKGROUND: Most reports of canine basal cell carcinomas (BCCs) focus on morphologic appearance rather than biologic behavior. Rare recurrences and no metastases have been reported in dogs. Quantitative nuclear morphometry may be useful in predicting tumor recurrence. OBJECTIVE: The aim of the present study was to compare quantitative nuclear parameters of canine BCCs that did not recur within 60 weeks of excision with those that recurred. METHODS: Cytologic specimens obtained from spontaneous BCCs from 11 dogs were analyzed by computerized nuclear morphometry. The dogs were monitored by their owners over a period of 60 weeks to detect local recurrence of the tumor; recurrent tumors were confirmed histologically. For each initial tumor specimen, nuclei of at least 100 neoplastic cells were measured by 2 independent observers, and mean nuclear area (MNA), mean nuclear perimeter (MNP), and mean nuclear diameter (MND) were calculated. RESULTS: Six nonrecurrent and 5 recurrent tumors were analyzed. Neoplastic cells from BCCs that subsequently recurred had higher MNA (102.41 +/- 4.57 microm(2)), MNP (36.27 +/- 0.61 microm), and MND (11.21 +/- 0.27 microm) than cells from nonrecurrent BCCs (MNA 87.66 +/- 4.79 microm(2), MNP 33.51 +/- 0.78 microm, MND 10.36 +/- 0.29 microm) (P<.001; Mann-Whitney U-test). CONCLUSION: Based on these preliminary results, nuclear morphometry may be a useful tool to predict local recurrence of BCCs in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19645743/