Peer-reviewed veterinary case report
How canine adenovirus type 2 strains cause respiratory illness in dogs
By Cao, Donglingzi et al.·Published in Microbial pathogenesis·2026·College of Animal Sciences and Veterinary Medicine, China·View original on PubMed →
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Original publication title: Comparative pathogenicity of wild-type and E3-deleted canine adenovirus type 2 in experimental canine infections.
- Species:
- dog
Plain-English summary
A group of dogs infected with canine adenovirus type 2 (CAdV-2) showed symptoms like coughing, nasal discharge, and fever after being exposed to the virus. The researchers found that both a new strain with a genetic mutation and the original strain caused similar respiratory issues, including inflammation in the trachea and lungs. All infected dogs had high levels of the virus in their respiratory tracts four days after infection. This study helps improve understanding of the virus and could aid in developing better vaccines to protect dogs from respiratory diseases.
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Abstract
Canine adenovirus type 2 (CAdV-2) is a major etiological agent of canine infectious respiratory disease (CIRD), responsible for acute laryngotracheitis and bronchopneumonia. In this study, we isolated and characterized three CAdV-2 strains from clinical cases in Guangxi, China. Among these, we identified a novel E3 gene variant (designated GXNN01) featuring a 9-nucleotide deletion, resulting in a 3-amino acid truncation. To access the pathogenicity of these strains, we conducted experimental infections in a canine model. All infected dogs developed transient fever (39.2-39.8 °C) and exhibited characteristic respiratory symptoms, including coughing and nasal discharge. High viral loads were detected in the tracheal and lungs at 4 days post-infection. Histopathological examination revealed acute tracheobronchitis and focal alveolar damage, consistent with the pathological manifestations of CAdV-2 infection. Notably, the E3-mutated strain demonstrated virulence comparable to that of wild-type isolates, suggesting functional redundancy in the E3 genomic region. These findings significantly enhance our understanding of CAdV-2 pathogenesis, provide valuable insights for vaccine development, and underscore the importance of continuous surveillance to track its global spread and impact on canine health.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41242570/