Peer-reviewed veterinary case report
Sildenafil drug levels after oral and rectal doses in healthy beagle
By Yang, Hyuck-Joo et al.·Published in BMC veterinary research·2018·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs.
- Species:
- dog
Plain-English summary
A group of healthy beagle dogs was given sildenafil, a medication used to treat pulmonary hypertension (PH), in different forms: as a tablet and as a dissolving film, both orally and rectally. The study found that both forms worked similarly when given by mouth, but the rectal method was quicker to take effect. No serious side effects were noted during the study. This suggests that the dissolving film could be a good option for dogs with PH, especially those that have trouble taking pills.
People also search for: beagle pulmonary hypertension treatment · sildenafil for dogs · how to give dog medication rectally
Abstract
BACKGROUND: Sildenafil citrate, a highly selective phosphodiesterase type 5 inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. The objective of this study was to investigate pharmacokinetic profiles by oral administration of orally disintegrating film (ODF) and film coated tablet (FCT) formulations and rectal administration of ODF formulation in healthy dogs. Twelve healthy beagle dogs were administered four separate doses of sildenafil: FCT formulation 2 mg/kg orally, ODF formulation 2 mg/kg orally, ODF formulation 2 mg/kg rectally, and ODF formulation 10 mg/kg rectally. For 24 hours following administration, blood samples were collected and the plasma concentrations of sildenafil were assayed by liquid chromatography-tandem mass spectrometry. RESULTS: There were no significant differences in all the pharmacokinetic parameters between FCT and ODF formulations when administrated orally. Cat the time of rectal administration was lower when the same dose was given as that orally administered. No serious systemic adverse events (AEs) were observed. CONCLUSIONS: These findings suggest that sildenafil ODF formulation can be used as an alternative to FCT formulation in the treatment of canine PH patients; additionally, rectal administration of sildenafil ODF may be a beneficial treatment option for canine patients who are unable to receive medication orally.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30249242/