Peer-reviewed veterinary case report
How fast Simparica and Advantix kill ticks on dogs
By Becskei, Csilla et al.·Published in Parasites & vectors·2016·Zoetis·View original on PubMed →
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Original publication title: Comparative speed of kill after treatment with Simparica™ (sarolaner) and Advantix®(imidacloprid + permethrin) against induced infestations of Dermacentor reticulatus on dogs.
- Species:
- dog
Plain-English summary
A group of dogs was treated with either Simparica (sarolaner) or Advantix (imidacloprid + permethrin) to see which worked better against ticks. Within just 8 hours, Simparica killed over 75% of the ticks, and by 24 hours, it eliminated all ticks, while Advantix only managed to kill about 48% at that time. Over the next 5 weeks, Simparica continued to effectively reduce tick counts after each re-infestation, showing a high level of effectiveness without any side effects. This means that Simparica is a reliable option for controlling ticks and preventing tick-borne diseases in dogs.
People also search for: dog tick treatment Simparica · how fast does Simparica work for ticks · Advantix effectiveness for ticks in dogs
Abstract
BACKGROUND: Ticks are common ectoparasites that infest dogs globally. Acaricides with rapid and sustained speed of kill are critical to control infestations and to reduce the risk of disease transmission. This study evaluated the speed of kill for 5 weeks after a single dose of orally administered Simparica™ (sarolaner) against induced infestations with Dermacentor reticulatus on dogs, compared to Advantix® Spot-on solution for dogs (imidacloprid + permethrin). METHODS: Twenty four dogs were randomly allocated to treatment with either a placebo tablet, a sarolaner tablet (at 2 to 4 mg/kg) or with Advantix® as per label instructions. Dogs were treated on Day 0 and tick counts were performed in situ at 8 and 12 hours and with removal of the ticks at 24 hours after treatment and subsequent re-infestations on Days 7, 14, 21, 28 and 35. Acaricidal efficacy was determined at each time point relative to live tick counts from the placebo-treated dogs. RESULTS: Based on arithmetic (geometric) mean tick counts, the efficacy of sarolaner was ≥75.6 % (89.6 %) within 8 hours of treatment and tick counts were significantly lower than placebo and imidacloprid + permethrin-treated dogs (P < 0.0001), while imidacloprid + permethrin had no significant reduction (P ≥ 0.3990) at 8 or 12 hours after treatment. Sarolaner killed all ticks on the dogs within 24 hours after treatment, while imidacloprid + permethrin efficacy was only 48.1 %. After weekly re-infestations sarolaner significantly reduced the tick counts versus placebo within 8 hours on Days 7, 14 and 35 (P ≤ 0.0239), and at 12 hours and 24 hours (P ≤ 0.0079) until Day 35.Sarolaner efficacy was ≥95.8 % within 24 hours for 35 days. Significantly more live ticks (P ≤ 0.0451) were recovered from imidacloprid + permethrin-treated dogs than from sarolaner-treated dogs at 24 hours after infestation on all days. There were no sarolaner-related adverse reactions during the study. CONCLUSIONS: This study demonstrated that Simparica™ had a faster and more consistent speed of kill against D. reticulatus compared to Advantix®. The rapid and consistent efficacy within 24 hours for 5 weeks after a single oral dose of Simparica™ provides effective and reliable control of D. reticulatus and reduces the risk of transmission of tick-borne diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26911323/