Comparative study oninfection in spleen and kidney of small mammals from Mile City and Lianghe County, Yunnan Province.

Abstract

BACKGROUND: Bartonellosis is a zoonotic infectious disease caused byspp. Small mammals are the most important hosts ofand play an important role in its long-term maintenance and spread. The multi-organ studies help understand theprevalence of hosts more systematically and comprehensively. This study aimed to investigate the prevalence ofin small mammals and explore the genetic diversity of the infected strains and the influencing factors from Mile City and Lianghe County, Yunnan Province. METHODS: Small mammals were captured in Mile City and Lianghe County of Yunnan Province from July to August 2019. Spleen and kidney tissues were collected and thegene was amplified to detect and analyze the prevalence ofin two regions and two organs. RESULTS: The prevalence ofin small mammals was 14.29% (43/301). Lianghe County's risk of infection was 3.79-fold (95%: 1.39-13.35) compared to that of Mile City. The risk of infection inwas increased by 90% compared to(95%: 0.01-0.63). The small mammals with tail lengths > 132 mm infected bywere 6.34 folds than that with tail lengths ≤ 132 mm (95%: 1.87-23.39). The spleen had a higher infection rate of 12.11% (35/289) than the kidney at 7.33% (22/300) (= 4.966,= 0.026). There were no statistically significant differences in the prevalence ofamong small mammals with different habitats, sex, age, flea infestation status, body weight, body length, hindfoot length, and ear height. Fivespecies were isolated in seven species of small mammalsis the dominant species in both regions, and it has a genetic relationship with the zoonotic pathogen. CONCLUSION: This study showed the prevalence ofin small mammals from Mile City and Lianghe County of Yunnan Province was high, and there were more types ofinfection species. The spleen was more conducive to the growth and reproduction of. The results of the study will help to prevent and controlinfection and transmission to humans from small mammals in the two regions and provide a reference basis for further research oninfection in Yunnan or other similar regions.