Peer-reviewed veterinary case report
Transcatheter closure of patent ductus arteriosus in children
By Markovic, L E et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Comparative transcatheter occlusion of patent ductus arteriosus: multicenter collaborative study across pediatric and veterinary cardiology centers.
- Species:
- dog
Plain-English summary
A group of 106 dogs with a heart condition called patent ductus arteriosus (PDA) underwent a minimally invasive procedure to close the abnormal blood vessel. Most of the dogs were treated successfully, with 93% having the device placed correctly. The most common method used for closure involved ligation of the vessel. This study shows that transcatheter PDA occlusion is effective in dogs, similar to results seen in children, and may help improve treatment practices for this condition in pets.
People also search for: dog heart condition treatment · patent ductus arteriosus in dogs · PDA closure procedure for dogs
Abstract
INTRODUCTION/OBJECTIVE: Transcatheter therapeutics have revolutionized treatment of patent ductus arteriosus (PDA). Greater understanding of corrective interventions across species can advance best practices, protocols, and outcomes while minimizing adverse events. The objective of this study was to describe characteristics and outcomes in children and dogs undergoing transcatheter PDA occlusion. ANIMALS, MATERIALS AND METHODS: This was a multicenter, retrospective cohort study from two pediatric and three veterinary centers. Demographics, procedural characteristics, and outcomes were assessed. RESULTS: Data included 202 children and 106 dogs treated from July 2019 to June 2021. Forty-five (23%) children and 19 (18%) dogs had congestive heart failure prior to catheterization. Transvenous and transarterial approaches for deployment were most used in children and dogs, respectively. All children had percutaneous vascular access compared to 17 (16%) dogs. Intraprocedural anticoagulation was standard for children (100% of 165 reported), but not for dogs (2/103). The median (interquartile range) pulmonary ostium diameter in children was 2.2 mm (1.5-3.0 mm) and 3.0 mm (2.0-4.2 mm) in dogs when all body sizes were considered (P<0.001). Amplatzer™ Duct Occluder was most commonly used in children (64/202, 32%); the Amplatz® Canine Duct Occluder was used in dogs (96/100, 96%). Closure was manual compression in all children, whereas vessel ligation was most used in dogs (74/104, 73%). Successful device deployment was achieved in 197 (98%) children and 98 (93%) dogs (P=0.03). Major reasons for failure included device embolization in six (2.9%) children and PDA morphology concerns in four (3.8%) dogs. CONCLUSIONS: Transcatheter PDA occlusion is successful in children and dogs. Study data might be useful for optimizing transcatheter therapeutics and animal models for interventional cardiology.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39357082/