Peer-reviewed veterinary case report
Fibrin network changes in a dog after ischemic stroke and clot
By Pretorius, Etheresia et al.·Published in The Onderstepoort journal of veterinary research·2010·Department of Anatomy·View original on PubMed →
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Original publication title: Comparative ultrastructure of fibrin networks of a dog after thrombotic ischaemic stroke.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog experienced a stroke after blood clots dislodged during a medical procedure. The dog showed signs of a cerebrovascular accident, which is rare in dogs but becoming more recognized. After the stroke, the dog was treated with a medication called streptokinase to dissolve the clots. Following treatment, tests showed that the dog's blood clot structure returned to normal, indicating that the treatment was effective.
People also search for: dog stroke symptoms · treatment for dog blood clots · mixed-breed dog stroke recovery
Abstract
A cerebrovascular accident or stroke is a rare condition in dogs, but previous studies suggest that it is now increasingly being recognised. Platelets and fibrin networks are involved in haemostasis,which is disrupted during a thrombotic event. In this study we investigate the ultrastructure of the fibrin networks of a dog that had suffered ischaemic stroke, following suspected thromboembolism from clots that became dislodged during catheter maintenance (flushing with heparinised saline) 2 days after carotid artery catheter insertion. Fibrin networks of blood samples that were collected immediately after the stroke, 15 min after treatment with streptokinase and 24 h after treatment, were studied. The results were compared to those of two control dogs. During a stroke, fibrin morphology changes to form a thick, matted layer.Post-treatment ultrastructure shows that the fibrin morphology returns to that comparable to controls. Our results show that during thrombotic risk, fibrin network morphology changes visibly and reduces the fibrinolytic activity of the coagulation system.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23327160/