Peer-reviewed veterinary case report
How remdesivir works in cats with feline infectious peritonitis
By Renner, Kelsey Ann et al.·Published in Journal of feline medicine and surgery·2026·Animal Referral Centre·View original on PubMed →
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Original publication title: Comparing the pharmacokinetics of GS-441524 after intravenous and oral administration of remdesivir in New Zealand cats with feline infectious peritonitis.
- Species:
- cat
Plain-English summary
Thirteen cats diagnosed with feline infectious peritonitis (FIP) were treated with either an intravenous (IV) or oral form of remdesivir, a medication used to help fight this disease. The study found that while the IV treatment resulted in higher levels of the active drug in the bloodstream, the oral version still provided a reasonable option for treatment, especially when the injectable form isn't available. Cats receiving oral remdesivir showed survival rates similar to those treated with the injectable form, making it a viable alternative.
People also search for: cat FIP treatment options · remdesivir for cats · feline infectious peritonitis survival rates
Abstract
ObjectivesThe aim of the study was to compare the pharmacokinetics of GS-441524 after intravenous (IV) and oral administration of compounded remdesivir (RDV) at 30 mg/kg, respectively, in cats with clinical feline infectious peritonitis (FIP) and to determine the bioavailability of GS-441524 after oral administration of compounded RDV in this population.MethodsA total of 13 client-owned cats with a clinical diagnosis of FIP were prospectively recruited. To reflect real-world use, RDV (30 mg/kg) was administered via a 20-min IV infusion or orally (rounded up to capsule size). Plasma GS-441524 concentrations were measured at eight time points over 24 h after administration. Pharmacokinetic parameters were determined by non-compartment analysis followed by bioavailability calculation.ResultsPharmacokinetic analysis of GS-441524 after administration of oral RDV achieved a mean (±SD)of 1083.36 ± 634.19 ng/ml (coefficient of variation [CV] 59%, range 254.18-1834.73) at a mean time of 5.33 ± 3.93 h (range 2-12) with a mean eliminationof 11.4 ± 8.00 h (range 4.58-27.01). In contrast, IV RDV administration produced a higher mean GS-441524of 6262.54 ± 1118.01 ng/ml (CV 18%, range 5193.40-8134.39) at a mean0.67 ± 0.26 h (range 0.5-1) with a mean eliminationof 6.8 ± 5.55 h (range 3.18-17.85). The mean relative bioavailability of GS-441524 after oral RDV was 30.13%. Bioavailability (range 12-52%) and time to maximum plasma concentrations (2-12 h) were highly variable.Conclusions and relevanceThe oral bioavailability of the compounded RDV used in this study is low, highly variable and appeared lower in cats with effusive disease, although this difference was not statistically significant. Given the small non-randomised sample, results should be interpreted considering the study limitations. Despite the low bioavailability, survival rates in cats treated with oral RDV are comparable to published outcome studies with injectable RDV and oral GS-441524, indicating that oral RDV is a viable treatment option when GS-441524 is not available.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41271601/