Peer-reviewed veterinary case report
Ki-67 and mitotic index compared for predicting dog mast cell tumor
By van Lelyveld, S et al.·Published in The Journal of small animal practice·2015·Dovecote Veterinary Hospital·View original on PubMed →
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Original publication title: Comparison between Ki-67 index and mitotic index for predicting outcome in canine mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at 162 dogs with mast cell tumors, a type of skin cancer, to see how two tests (the Ki-67 index and mitotic index) could predict survival. They found that a high Ki-67 index could indicate a higher risk of death, but it wasn't very specific, meaning not all dogs with a high score died from the cancer. On the other hand, a high mitotic index (more than 5) was very specific for predicting death, but not very sensitive, meaning it missed some cases. The researchers suggest that using a combination of these tests could help vets better predict outcomes for dogs with mast cell tumors.
People also search for: dog mast cell tumor prognosis · Ki-67 index in dogs · mitotic index for dog cancer
Abstract
OBJECTIVES: To assess correlation between Ki67 index and mitotic index and determine which more accurately predicts survival in canine mast cell tumours. METHODS: Retrospective analysis of cases from three UK referral hospitals. Correlation between Ki67 index and mitotic index was assessed and survival analysis performed. RESULTS: A total of 162 dogs were included: 57 dogs died with 37 due to mast cell tumour. Correlation between Ki67 index and mitotic index was moderate, while the agreement was poor. A high Ki67 index was considered sensitive (86 · 5%) at predicting mast cell tumour-related death, but poorly specific (57 · 9%). Mitotic index(>5) was poorly sensitive (32 · 4%), but highly specific (96%). A mitotic index of ê2 had a 75 · 7% sensitivity and an 80 · 0% specificity. Ki67 index showed a statistically significant survival difference within the mitotic index <2 (P = 0 · 009) group. Ki67 index did not predict survival rate in tumours with mitotic index of ê2. CLINICAL RELEVANCE: Correlation between Ki67 and mitotic index is moderate. High mitotic index accurately predicted death, but many dogs with low mitotic index also died. Low Ki67 accurately predicted survival, but high Ki67 should not be considered a poor prognostic indicator. A three-tier mitotic index assessment may more accurately predict death due to mast cell tumour.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25728289/