Peer-reviewed veterinary case report
Predicting metastasis in dogs with mast cell tumors using 2
By Stefanello, Damiano et al.·Published in Journal of the American Veterinary Medical Association·2015·Department of Veterinary Sciences and Public Health, Italy·View original on PubMed →
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Original publication title: Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009-2014).
- Species:
- dog
Plain-English summary
A study looked at 386 dogs with skin tumors called cutaneous mast cell tumors (MCTs) to see how well two different grading systems predicted whether the tumors had spread (metastasized) at the time of diagnosis. The researchers found that dogs with higher-grade tumors were more likely to have metastases. However, some dogs with lower-grade tumors also had metastatic disease, suggesting that the tumor grade alone isn't enough to determine the risk of spread. It's important for pet owners to discuss both the tumor grade and the results of clinical staging with their veterinarian for a better understanding of their dog's condition.
People also search for: dog skin tumor metastasis · mast cell tumor grading in dogs · cutaneous mast cell tumor treatment
Abstract
OBJECTIVE: To compare the Kiupel (2 categories) and Patnaik (3 categories) histologic grading systems for predicting the presence of metastasis at the time of initial examination in dogs with cutaneous mast cell tumors (MCTs). DESIGN: Retrospective case series. ANIMALS: 386 client-owned dogs with cutaneous MCTs. PROCEDURES: Medical records of dogs with newly diagnosed, histologically confirmed cutaneous MCTs that had undergone complete clinical staging were reviewed for clinical and histopathologic data. RESULTS: All Patnaik grade 1 MCTs (n = 52) were classified as Kiupel low-grade MCTs, and all Patnaik grade 3 MCTs (43) were classified as Kiupel high-grade MCTs. Of the 291 Patnaik grade 2 MCTs, 243 (83.5%) were classified as Kiupel low-grade tumors, and 48 (16.5%) were classified as Kiupel high-grade MCTs. Dogs with Patnaik grade 3 MCTs were significantly more likely to have metastases at the time of initial examination than were dogs with grade 1 or 2 MCTs (OR, 5.46), and dogs with Kiupel high-grade MCTs were significantly more likely to have metastases than were dogs with Kiupel low-grade MCTs (OR, 2.54). However, 3 of 52 (5.8%) dogs with Patnaik grade 1 tumors, 48 of 291 (16.5%) dogs with Patnaik grade 2 tumors, and 44 of 295 (14.9%) dogs with Kiupel low-grade tumors had metastatic disease. CONCLUSIONS AND CLINICAL RELEVANCE: Findings indicated that in dogs with cutaneous MCTs, prognostication should not rely on histologic grade alone, regardless of grading system used, but should take into account results of clinical staging.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25794126/