Peer-reviewed veterinary case report
Differences in immune cells and cytokines in dogs with atopic
By Verde, María Teresa et al.·Published in Research in veterinary science·2022·Animal Pathology Department, Spain·View original on PubMed →
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Original publication title: Comparison of circulating CD4, CD8lymphocytes and cytokine profiles between dogs with atopic dermatitis and healthy dogs.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis, a skin condition that causes itching and inflammation, was compared to healthy dogs to understand their immune response. The atopic dogs had a higher number of certain immune cells (CD8 lymphocytes) and different levels of specific proteins (cytokines) in their blood, which were linked to the severity of their skin issues. This suggests that measuring these immune cells and cytokines could help veterinarians assess how severe a dog's atopic dermatitis is and aid in diagnosis.
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Abstract
INTRODUCTION: Canine atopic dermatitis (cAD) is an inflammatory skin disease characterized by impaired immune function. Changes in the proportions of CD4and CD8lymphocytes and the serum concentrations of cytokines in the pathogenesis of cAD have been described. OBJECTIVES: To assess whether the changes in the ratio of CD4and CD8lymphocytes in the peripheral blood of atopic dogs at the time of diagnosis are related to the severity of the disease. Furthermore, we determined whether the changes in the serum concentrations of the cytokines IL-31, IL-34, IL-10, IFN-γ, and TNF-α were different between atopic and control dogs. PROCEDURES: Fifty-six client-owned dogs with atopic dermatitis and 53 healthy control dogs were used. The percentages of CD4and CD8lymphocytes were determined by imaging flow cytometry. The index of CADESI-03 was calculated. Serum cytokine levels were analyzed using ELISA. RESULTS: Atopic dogs showed a higher percentage of CD8lymphocytes, a lower CD4/CD8ratio than healthy dogs, and a positive correlation with CADESI-03. Atopic dogs also showed higher serum IL-31 and IL-34 levels and lower IL-10 levels. A moderate positive correlation was found between serum IL-31 and CADESI-03. CONCLUSIONS: The CD4/CD8ratio may be a sensitive parameter that positively correlates with the severity of cAD, and elevated serum levels of IL-31 and IL-34 may facilitate diagnosis of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35134678/