Peer-reviewed veterinary case report
Inflammation markers in dogs with pyometra before and after surgery
By Ahn, Soomin et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2021·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.
- Species:
- dog
Plain-English summary
A 5-year-old female dog was diagnosed with pyometra, a serious infection of the uterus, and was brought in for treatment. After surgery to remove the inflamed uterus, the dog's inflammatory markers showed improvement, indicating a positive response to the treatment. The levels of certain proteins related to inflammation decreased significantly after the surgery, suggesting that the procedure was effective in helping the dog recover. Monitoring these markers can help veterinarians assess recovery in similar cases.
People also search for: dog pyometra symptoms · female dog surgery recovery · pyometra treatment in dogs
Abstract
This study aimed to identify potential biomarkers of canine pyometra and their correlations with clinical parameters. First, 90 dogs with pyometra and 26 healthy female dogs were compared. Then, paired samples (before and after ovariohysterectomy) from 22 dogs with pyometra and 9 healthy controls from the initial cohort were compared. Concentrations of acute inflammatory proteins, C-reactive protein (CRP) and serum amyloid A (SAA), and cell-free DNA (cfDNA), were significantly higher in dogs with pyometra than in clinically healthy dogs. Cell-free DNA was the most sensitive biomarker for systemic inflammation, based on the receiver operating characteristic curve analysis (area under the curve = 0.959). In addition, cfDNA and CRP were significantly associated with inflammation and organ injury-related clinical parameters. Following the surgical removal of the inflamed uterus, interleukin-6 (IL-6), high-mobility group box 1 (HMGB1), and procalcitonin (PCT) significantly decreased, whereas changes in CRP, SAA, and cfDNA were not significant. These findings indicate that cfDNA, CRP, and SAA are potential clinical biomarkers of systemic inflammation in dogs with pyometra and PCT, IL-6, and HMGB1 are potential biomarkers of clinical recovery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34602731/