Peer-reviewed veterinary case report
Low vitamin D levels in dogs with chronic inflammatory bowel disease
By Wennogle, Sara A et al.·Published in Journal of veterinary internal medicine·2019·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25-hydroxycholecalciferol concentrations.
- Species:
- dog
Plain-English summary
A group of dogs with chronic inflammatory enteropathy (CIE), which causes digestive issues, were studied to understand why some had low vitamin D levels. The dogs with low vitamin D showed more severe symptoms and lower levels of important nutrients like cholesterol and albumin compared to those with normal vitamin D levels. The researchers found that the inflammation in the intestines might be linked to the low vitamin D, suggesting that fat absorption issues could be a factor. This means that if your dog has CIE and low vitamin D, it might be worth discussing dietary adjustments with your vet to help improve their condition.
People also search for: dog chronic inflammatory enteropathy treatment · low vitamin D in dogs · dog digestive problems and vitamin deficiency
Abstract
BACKGROUND: The cause of low serum vitamin D concentrations in dogs with chronic inflammatory enteropathy (CIE) is not well understood. OBJECTIVE: Improve understanding of pathogenesis of low serum vitamin D concentrations in dogs with CIE by comparing several clinical, clinicopathologic, and histologic variables between CIE dogs with low and normal serum 25-hydroxyvitamin D concentrations (25[OH]D). ANIMALS: Fifteen dogs with CIE and low serum 25[OH]D concentrations; 15 dogs with CIE and normal serum 25(OH)D concentrations. METHODS: Prospective cohort study. Clinical and clinicopathologic variables were compared between groups. Correlations between serum 25(OH)D concentration and histopathologic variables were assessed. RESULTS: Dogs with CIE and low serum 25(OH)D concentrations had higher canine chronic enteropathy clinical activity index scores (P = .003), lower serum α-tocopherol (P < .001), cholesterol (P < .001), and albumin (P < .001) concentrations and higher serum C-reactive protein (P = .004) concentrations compared to CIE dogs with normal serum 25(OH)D concentrations. Serum concentrations of vitamin D-binding protein (VDBP) were not different between groups (P = .91). Duodenal morphologic and inflammatory histopathological scores (P = .002 and P = .004, respectively) and total histopathological scores in duodenum and combined duodenum and ileum negatively correlated with serum 25(OH)D concentration. CONCLUSIONS AND CLINICAL IMPORTANCE: The pathogenesis of low serum vitamin D concentrations in dogs with CIE is likely multifactorial. Fat malabsorption deserves further study in dogs with low serum vitamin D concentration and CIE. Loss of VDBP does not appear to be an important cause of low serum vitamin D concentration in dogs with CIE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31496004/