Peer-reviewed veterinary case report
Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids.
- Journal:
- Emerging infectious diseases
- Year:
- 2025
- Authors:
- Flagg, Meaghan et al.
- Species:
- bird
Abstract
We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39778080/