Peer-reviewed veterinary case report
Oral vs injection B12 for low cobalamin in dogs with gut disease
By Toresson, L et al.·Published in Veterinary journal (London, England : 1997)·2018·Department of Equine and Small Animal Medicine·View original on PubMed →
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Original publication title: Comparison of efficacy of oral and parenteral cobalamin supplementation in normalising low cobalamin concentrations in dogs: A randomised controlled study.
- Species:
- dog
Plain-English summary
A group of dogs with chronic digestive issues and low vitamin B12 levels were given either daily oral cobalamin tablets or injections of cobalamin to see which worked better. After 28 days, all the dogs showed improved vitamin B12 levels, with both treatments being effective. The injection group had higher levels than the oral group, but both methods brought the dogs' vitamin levels back to normal. This means that whether you choose oral or injectable cobalamin, your dog can benefit from increased vitamin B12 if they have low levels due to chronic digestive problems.
People also search for: dog low vitamin B12 treatment · cobalamin injections for dogs · oral cobalamin for dogs with digestive issues
Abstract
The aim of this study was to compare the efficacies of parenteral and oral cobalamin supplementation protocols in dogs with chronic enteropathies and low cobalamin concentrations. It was hypothesised that both treatments would increase serum cobalamin concentrations significantly. Fifty-three dogs with chronic enteropathies and serum cobalamin concentrations<285ng/L (reference interval 244-959ng/L) were enrolled. Dogs were randomised to treatment with either daily oral cobalamin tablets (0.25-1.0mg cyanocobalamin daily according to body weight) or parenteral cobalamin (0.4-1.2mg hydroxycobalamin according to body weight). Serum cobalamin concentrations were analysed 28±5days and 90±15days after initiation of supplementation. After 28 days, all dogs had serum cobalamin concentrations within the reference interval or above. In the parenteral group (n=26), median (range) cobalamin concentrations were 228 (150-285) ng/L at inclusion, 2107 (725-10,009) ng/L after 28days and 877 (188-1267) ng/L after 90 days. In the oral group (n=27), median (range) serum cobalamin concentrations were 245 (150-285) ng/L at inclusion, 975 (564-2385) ng/L after 28days and 1244 (738-4999) ng/L after 90 days. In both groups, there were significant differences in serum cobalamin concentrations between baseline and 28 days, and between 28days and 90days (P<0.001). In conclusion, both parenteral and oral cobalamin supplementation effectively increase serum cobalamin concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29428088/