Peer-reviewed veterinary case report
Comparison of electrocardiographic recordings in open-chest and closed-chest swine models.
- Journal:
- Journal of the American Association for Laboratory Animal Science : JAALAS
- Year:
- 2010
- Authors:
- Shousha, Sherif et al.
- Affiliation:
- Faculty of Pharmacy · Canada
Abstract
The aim of our study was to compare the electrocardiographic recordings in an experimental open-chest swine model before and after left-sided thoracotomy to detect any surgery-induced fluctuations that might interfere with subsequent experimental interventions. We obtained electrocardiograms from 8 deeply anesthetized domestic swine and compared the respective ST-segment potentials obtained after vascular surgery and after left-sided thoracotomy and dissection of the left anterior descending coronary artery. Compared with baseline recordings, no significant ST-segment deviation on any of the electrocardiographic leads occurred after vascular surgery. However, statistically significant ST-segment depression was observed after thoracotomy. Invasive surgical procedures in open-chest swine models may lead to morphologic changes in the ST segment. The physiologic mechanism of these changes is not fully understood.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21205452/