Peer-reviewed veterinary case report
Are ileal biopsies needed for diagnosing dog intestinal disease?
By Casamian-Sorrosal, D et al.·Published in Journal of veterinary internal medicine·2010·Department of Clinical Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: Comparison of histopathologic findings in biopsies from the duodenum and ileum of dogs with enteropathy.
- Species:
- dog
Plain-English summary
A group of 40 dogs with chronic diarrhea underwent biopsies from both the duodenum and ileum to check for intestinal problems. The results showed that only a small number of dogs had the same diagnosis from both areas, suggesting that issues might be missed if only one type of biopsy is done. In fact, more abnormalities were found when both duodenal and ileal samples were collected. This means that if your dog has ongoing diarrhea, your vet might recommend taking biopsies from both parts of the intestine to get a clearer picture of what’s going on.
People also search for: dog chronic diarrhea treatment · dog intestinal biopsy results · why is my dog having diarrhea
Abstract
BACKGROUND: In the investigations of dogs with chronic small intestinal diarrhea collection of ileal biopsies lengthens procedural time and has been of uncertain value. OBJECTIVES: To evaluate whether there was agreement between histologic changes present in samples of duodenal and ileal mucosa, and hence to provide initial information in the process of determining whether collection of ileal biopsies is clinically justified. ANIMALS: 40 dogs with chronic small and large intestinal diarrhea from which endoscopic (in 30 cases) or surgical (in 10 cases) duodenal and ileal biopsies had been collected. METHODS: Samples were reviewed concurrently by two observers (MJD and MDW) using the scoring system developed by the World Small Animal Veterinary Association (WSAVA) Gastrointestinal Standardization Group. Comparisons were made by kappa analysis. RESULTS: Microscopic pathology was observed in 30 cases. Only eight out of this 30 (27%) had the same histopathologic diagnosis in both the duodenum and the ileum. This dropped to 3 out of 30 (10%) if different disease severity was also considered as disagreement. Microscopic pathology would have been found in 60% and 80% of the 30 cases, if only duodenal or ileal biopsies respectively, had been available. CONCLUSIONS AND CLINICAL IMPORTANCE: There was poor agreement between histopathological findings from duodenal versus ileal biopsies with abnormalities sometimes being more readily detected in the ileum. Routine collection of ileal plus duodenal samples appears warranted when concurrent small and large intestinal diarrhea is present.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20002555/