Peer-reviewed veterinary case report
Lente vs NPH insulin for newly diagnosed diabetic dogs
By Fracassi, Federico et al.·Published in The Veterinary record·2018·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: Comparison of lente insulin and NPH insulin therapy for the treatment of newly diagnosed diabetic dogs: a randomised study.
- Species:
- dog
Plain-English summary
A group of 30 newly diagnosed diabetic dogs were treated with either lente insulin or NPH insulin to see which worked better. Both types of insulin were given every 12 hours, and the dogs were monitored over 12 weeks. Owners noticed improvements in symptoms like excessive thirst and urination, and blood sugar levels improved in both groups. By the end of the study, both insulin types were found to be similarly effective in managing diabetes in dogs, with many achieving good blood sugar control.
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Abstract
Clinical studies that compare lente insulin and neutral protamine Hagedorn (NPH) insulin in diabetic dogs are lacking. This is a prospective, randomised, controlled clinical study aimed to compare the efficacy and safety of lente insulin and NPH insulin in diabetic dogs. Thirty client-owned, newly diagnosed diabetic dogs were included. Animals were randomised into two groups and received lente insulin or NPH insulin administered every 12 hours. Follow-up re-evaluations were done at 1, 2, 4, 6, 8 and 12 weeks. At each re-evaluation, a physical exam, blood glucose curve, and serum fructosamine concentrations were performed. At the end of the study, the median insulin dose per injection was 0.61 U/kg (range, 0.34-0.92 U/kg) and 0.49 U/kg (range, 0.23-0.68 U/kg) in the lente and NPH groups, respectively. There was a significant improvement of polyuria and polydipsia and glucose concentrations in both groups. At the end of the study, the glycaemic control was considered good in 9/15 (60 per cent) and 11/15 (73 per cent) in the lente and NPH groups, respectively. These differences were not significant. Lente insulin and NPH insulin were similarly effective in the treatment of dogs with diabetes mellitus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30030413/