Peer-reviewed veterinary case report
Comparison of lente insulin and NPH insulin therapy for the treatment of newly diagnosed diabetic dogs: a randomised study.
- Journal:
- The Veterinary record
- Year:
- 2018
- Authors:
- Fracassi, Federico et al.
- Affiliation:
- Department of Veterinary Medical Sciences · Italy
- Species:
- dog
Plain-English summary
This study looked at two types of insulin, lente insulin and NPH insulin, to see which one works better for dogs newly diagnosed with diabetes. Thirty dogs were included in the study and were divided into two groups, with each group receiving one type of insulin every 12 hours. The dogs were checked regularly over 12 weeks to monitor their health and blood sugar levels. Both types of insulin helped improve symptoms like excessive drinking and urination, and both were effective in managing blood sugar levels. In the end, both lente and NPH insulin were found to work similarly well for treating diabetes in dogs.
Abstract
Clinical studies that compare lente insulin and neutral protamine Hagedorn (NPH) insulin in diabetic dogs are lacking. This is a prospective, randomised, controlled clinical study aimed to compare the efficacy and safety of lente insulin and NPH insulin in diabetic dogs. Thirty client-owned, newly diagnosed diabetic dogs were included. Animals were randomised into two groups and received lente insulin or NPH insulin administered every 12 hours. Follow-up re-evaluations were done at 1, 2, 4, 6, 8 and 12 weeks. At each re-evaluation, a physical exam, blood glucose curve, and serum fructosamine concentrations were performed. At the end of the study, the median insulin dose per injection was 0.61 U/kg (range, 0.34-0.92 U/kg) and 0.49 U/kg (range, 0.23-0.68 U/kg) in the lente and NPH groups, respectively. There was a significant improvement of polyuria and polydipsia and glucose concentrations in both groups. At the end of the study, the glycaemic control was considered good in 9/15 (60 per cent) and 11/15 (73 per cent) in the lente and NPH groups, respectively. These differences were not significant. Lente insulin and NPH insulin were similarly effective in the treatment of dogs with diabetes mellitus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30030413/