Peer-reviewed veterinary case report
MCM7 protein helps predict survival in dogs with medium-grade skin
By Berlato, D et al.·Published in Veterinary and comparative oncology·2018·Centre for Small Animal Studies, United Kingdom·View original on PubMed →
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Original publication title: Comparison of minichromosome maintenance protein 7, Ki67 and mitotic index in the prognosis of intermediate Patnaik grade cutaneous mast cell tumours in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with intermediate-grade skin tumors called mast cell tumors (MCTs) were studied to see how certain tests could help predict their outcomes after surgery. Out of 90 dogs, most were alive after more than three years, but 18 dogs died from MCT-related issues within about four months. The study found that tests measuring specific proteins (MCM7 and Ki67) could help predict which dogs were at higher risk of dying from these tumors. Using a combination of these tests improved the accuracy of predictions, suggesting that they could be useful for veterinarians when assessing treatment options for dogs with MCTs.
People also search for: dog mast cell tumor prognosis · Ki67 test for dog tumors · MCM7 in dogs with cancer
Abstract
A previous study found that minichromosome maintenance protein 7 (MCM7) score was associated with prognosis in dogs with cutaneous mast cell tumours (MCTs) independent of histological grade. The primary aim of this study was to validate this score in a different cohort of dogs focusing exclusively on patients with Patnaik intermediate grade MCTs treated with surgery alone and followed for a minimum of 1 year. A secondary aim was to evaluate the prognostic performance of MCM7 in relation to Kiupel histological grade, mitotic index (MI) and Ki67 index in the same cohort of dogs. Ninety dogs were identified, 82 were low Kiupel grade and 8 were high Kiupel grade. Seventy-two dogs were alive after a median follow-up of 1136 days and 18 dogs died of MCT-related causes after a median of 116 days. A MI threshold of 5 was associated with a sensitivity of 0.39 and a specificity of 0.99 in predicting MCT-related death; for Ki67 a threshold of 0.018 was associated with a sensitivity of 0.78 and a specificity of 0.83; and for MCM7 a threshold of 0.18 gave a sensitivity of 0.83 and a specificity of 0.86. Combining MI, Ki67 and MCM7 showed an improved accuracy of predicting death compared with each individual variable. Therefore, performing Ki67 and MCM7 in dogs with GII MCT, low Kiupel grade and low MI might be a consideration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29989314/