Peer-reviewed veterinary case report
Ki67 and mitotic index predict survival in dogs with skin mast cell
By Berlato, D et al.·Published in Veterinary and comparative oncology·2015·Centre for Small Animal Studies, United Kingdom·View original on PubMed →
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Original publication title: Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A group of 95 dogs with skin tumors called mast cell tumors (MCTs) were studied to see how certain markers could predict their survival. Researchers looked at two specific markers, Ki67 and mitotic index, to determine how they related to the dogs' prognosis. They found that both markers could help identify which tumors were more likely to lead to a shorter life. This information can help veterinarians decide on more aggressive treatments for dogs with intermediate-grade MCTs, potentially improving their outcomes.
People also search for: dog mast cell tumor prognosis · Ki67 index in dogs · treatment for canine skin tumors
Abstract
Proliferation markers are commonly used for prognostication of mast cell tumours. The aim of the study is to compare the relative abilities of Ki67 and mitotic index to predict survival in the same cohort of dogs with cutaneous MCTs. Histological grade, mitotic index and Ki67 index were performed in all samples and clinical information was obtained by a follow-up questionnaire. Ninety-five dogs were included in the study with a median follow-up of 1145 days. Survival times varied significantly between categories of histological grade, mitotic index and Ki67 index. Multivariable analyses showed that the risk of dying due to MCT was similar in dogs with increased Ki67 index [hazard ratio, HR: 3.0 (95% CI 1.3-6.8)] or increased mitotic index [HR: 2.7 (95% CI 1.1-6.5)]. In conclusion, both mitotic index and Ki67 index were able to independently differentiate MCTs with worse prognosis. This distinction is particularly meaningful in selecting intermediate grade MCTs that may benefit from more aggressive local or systemic treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23489679/