Peer-reviewed veterinary case report
How blood tests show heart disease stages in dogs with mitral valve
By Ogawa, Mizuki et al.·Published in The Journal of veterinary medical science·2021·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Comparison of N-terminal pro-atrial natriuretic peptide and three cardiac biomarkers for discriminatory ability of clinical stage in dogs with myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A study found that dogs with myxomatous mitral valve disease (MMVD), a common heart condition, showed increased levels of certain blood markers as their disease progressed. Specifically, the markers NT-proANP and NT-proBNP were effective in identifying dogs with heart enlargement and congestive heart failure (CHF). The researchers compared these markers in dogs with MMVD and healthy dogs, finding that higher levels of NT-proANP and NT-proBNP were associated with more severe heart issues. This information can help veterinarians better diagnose and manage heart disease in dogs.
People also search for: dog heart disease symptoms · myxomatous mitral valve disease treatment · NT-proANP in dogs
Abstract
Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) concentration increases with progression of myxomatous mitral valve disease (MMVD) in dogs. This multicentre, prospective study compared plasma NT-proANP, N-terminal pro-brain natriuretic peptide (NT-proBNP), ANP, and cardiac troponin I (cTnI) concentrations in dogs with MMVD for their characteristics and discriminatory ability to detect cardiac dilatation and congestive heart failure (CHF). Thirty-six healthy dogs and 69 dogs with MMVD were included. Clinical variables were obtained via physical examination, thoracic radiography, and echocardiography. The discriminatory ability of each cardiac biomarker (CB) to determine the presence or absence of cardiac dilatation (event 1) and CHF (event 2) was evaluated using the receiver operating characteristic curves. Plasma NT-proANP, NT-proBNP, and ANP concentrations showed a significant association with the left atrium/aorta ratio (P<0.01). The area under the curve of plasma NT-proANP and NT-proBNP concentrations were 0.72 and 0.75, respectively in event1 and 0.72 and 0.76, respectively in event2. Plasma NT-proANP and NT-proBNP concentrations showed sensitivity 80.0 and 80.0%; specificity 67.6 and 64.7% in event1 (cutoff value; 8,497.81 pg/ml and 1,453.00 pmol/l, respectively) and sensitivity 85.7 and 81.0%; specificity 60.4 and 64.6% in event2 (cutoff value; 8,684.33 pg/ml and 1,772.00 pmol/l, respectively). In dogs with MMVD, plasma NT-proANP, NT-proBNP, and ANP concentrations increase with left atrial enlargement. Particularly, plasma NT-proANP and NT-proBNP concentrations appeared to be equally useful in the discriminatory ability to detect cardiac dilatation and CHF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33551383/