Peer-reviewed veterinary case report
Treatment comparison of lomustine plus prednisolone versus
By Flegel, Thomas et al.·Published in Journal of the American Veterinary Medical Association·2011·Department of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with granulomatous meningoencephalomyelitis (GME) or necrotizing encephalitis (NE) were treated with either a combination of lomustine and prednisolone or prednisolone alone. The dogs receiving both medications had a median survival time of about 457 days, while those on prednisolone alone lived around 329 days. Both treatments were effective, but the combination allowed for a greater reduction in prednisolone dosage over time. Overall, the combination treatment was well-tolerated, with some dogs experiencing mild side effects like low white blood cell counts.
People also search for: dog GME treatment · necrotizing encephalitis in dogs · lomustine for dogs · prednisolone side effects in dogs
Abstract
OBJECTIVE: To compare oral administration of lomustine and prednisolone with oral administration of prednisolone alone as treatment for granulomatous meningoencephalomyelitis (GME) or necrotizing encephalitis (NE) in dogs. DESIGN: Retrospective cohort study. ANIMALS: 25 dogs with GME and 18 dogs with NE (diagnosis confirmed in 8 and 5 dogs, respectively). PROCEDURES: Records of dogs with GME or NE were reviewed for results of initial neurologic assessments and clinicopathologic findings, treatment, follow-up clinicopathologic findings (for lomustine-treated dogs), and survival time. Dogs with GME or NE treated with lomustine and prednisolone were assigned to groups 1 (n = 14) and 3 (10), respectively; those treated with prednisolone alone were assigned to groups 2 (11) and 4 (8), respectively. RESULTS: Prednisolone was administered orally every 12 hours to all dogs. In groups 1 and 3, mean lomustine dosage was 60.3 mg/m², PO, every 6 weeks. Median survival times in groups 1 through 4 were 457, 329, 323, and 91 days, respectively (no significant difference between groups 1 and 2 or between groups 3 and 4). Within the initial 12 months of treatment, median prednisolone dosage was reduced in all groups; dosage reduction in group 1 was significantly larger than that in group 2 at 6, 9, and 12 months. Combination treatment most frequently caused leukopenia, but had no significant effect on liver enzyme activities. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs with GME and NE, oral administration of lomustine and prednisolone or prednisolone alone had similar efficacy. Inclusion of lomustine in the treatment regimen was generally tolerated well.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21281217/