Comparison of passive transfer of immunity in neonatal dairy calves fed colostrum or bovine serum-based colostrum replacement and colostrum supplement products.

Abstract

OBJECTIVE: To compare serum total protein (sTP) and serum IgG (sIgG) concentrations In neonatal calves administered colostrum or a bovine serum-based colostrum replacement (CR) product followed by a bovine serum-based colostrum supplement (CS) product. DESIGN: Randomized controlled clinical trial. ANIMALS: 18 Jersey and 269 Holstein neonatal heifer calves. PROCEDURES: 141 calves were given 4 L of colostrum in 1 or 2 feedings (first or only feeding was provided&#x2264;2 hours after birth; when applicable, a second feeding was provided between 2 and 12 hours after birth). Other calves (n=146) were fed 2 L of a CR product&#x2264;2 hours after birth and then 2 L of a CS product between 2 and 12 hours after birth. Concentrations of sTP and sIgG were measured 1 to 7 days after birth. Data from cohorts on individual farms and for all farms were analyzed. RESULTS: Mean sTP and sIgG concentrations differed significantly between feeding groups. In calves fed colostrum and calves fed CR and CS products, mean&#xb1;SD sTP concentration was 5.58&#xb1;0.67 g/dL and 5.26&#xb1;0.54 g/dL, respectively, and mean sIgG concentration was 1,868&#xb1;854 mg/dL and 1,320&#xb1;620 mg/dL, respectively. The percentage of calves that had failure of passive transfer of immunity (ie, sIgG concentrations<1,000 mg/dL) was not significantly different between groups. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that sequential feeding of bovine serum-based CR and CS products to neonatal calves is an alternative to feeding colostrum for achieving passive transfer of immunity.