Peer-reviewed veterinary case report
Osteocrin levels after two types of knee surgery in dogs
By Isaka, Mitsuhiro et al.·Published in Research in veterinary science·2023·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Comparison of perioperative serum osteocrin concentrations between surgical techniques in dogs with cranial cruciate ligament rupture.
- Species:
- dog
Plain-English summary
A group of dogs with torn knee ligaments (cranial cruciate ligament rupture) underwent two different types of surgery: tibial plateau leveling osteotomy (TPLO) and extracapsular lateral suture (ECLS). After the TPLO surgery, blood tests showed a significant drop in a bone-related protein called osteocrin, which may indicate some level of bone injury during the procedure. However, the ECLS group did not show any significant changes in osteocrin levels. This suggests that the TPLO surgery might have more impact on bone healing compared to the ECLS method.
People also search for: dog knee surgery recovery · TPLO surgery effects · cranial cruciate ligament rupture treatment
Abstract
The cranial cruciate ligament (CCL) rupture is a common orthopedic disease in dogs that is usually managed with tibial plateau leveling osteotomy (TPLO) or extracapsular lateral suture (ECLS). Osteotomy is generally associated with some complications, including nonunion. The periosteum plays an important role in bone growth and remodeling. Osteocrin (OSTN), which was recently identified and is involved in bone formation and differentiation, is produced in the periosteum and osteoblasts. The aimed to investigate whether the concentrations of serum OSTN change before and after stifle surgery in dogs and compare the OSTN concentrations in the two surgical techniques (TPLO: n = 20 vs. ECLS: n = 36). The postoperative serum OSTN concentration in the TPLO group was significantly lower than the preoperative value (p < 0.05), while serum OSTN concentrations differed statistically between the preoperative and suture-removal periods. In contrast, no significant differences were observed in the ECLS group. In conclusion, osteotomy affects serum OSTN concentrations during the perioperative period in dogs, which may be related to periosteal injury.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36917865/