Peer-reviewed veterinary case report
Plasma troponin I levels in dogs with heart and other hemangiosarcomas
By Chun, Ruthanne et al.·Published in Journal of the American Veterinary Medical Association·2010·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Comparison of plasma cardiac troponin I concentrations among dogs with cardiac hemangiosarcoma, noncardiac hemangiosarcoma, other neoplasms, and pericardial effusion of nonhemangiosarcoma origin.
- Species:
- dog
Plain-English summary
A study looked at 57 dogs with different types of hemangiosarcoma (a type of cancer) and other conditions to see if a blood test measuring cardiac troponin I (cTnI) could help identify heart involvement. Dogs with cardiac hemangiosarcoma had significantly higher cTnI levels compared to those with noncardiac hemangiosarcoma or other tumors. If a dog's cTnI level is above 0.25 ng/mL, it could indicate heart involvement, especially in cases of pericardial effusion (fluid around the heart). This test could help veterinarians diagnose heart issues related to hemangiosarcoma more effectively.
People also search for: dog hemangiosarcoma symptoms · dog heart cancer treatment · elevated troponin levels in dogs
Abstract
OBJECTIVE: To determine whether plasma cardiac troponin I (cTnl) concentrations can be used to identify cardiac involvement in dogs with hemangiosarcoma, exclude cardiac hemangiosarcoma in dogs with noncardiac hemangiosarcoma, and identify cardiac hemangiosarcoma in dogs with pericardial effusion. DESIGN: Cohort study. ANIMALS: 57 dogs (18 with confirmed [5 dogs] or suspected [13] cardiac hemangiosarcoma, 14 with confirmed hemangiosarcoma involving sites other than the heart [noncardiac hemangiosarcoma], 10 with pericardial effusion not caused by hemangiosarcoma, and 15 with noncardiac nonhemangiosarcoma neoplasms). PROCEDURES: Plasma cTnl concentration was measured, and thoracic radiography, abdominal ultrasonography, and echocardiography were performed in each dog. The cTnl concentration was compared among groups. RESULTS: Median plasma cTnl concentration in dogs with cardiac hemangiosarcoma was significantly higher than the concentration in each of the other groups. A plasma cTnl concentration > 0.25 ng/mL could be used to identify cardiac involvement in dogs with hemangiosarcoma at any site (sensitivity, 78%; specificity, 71 %). A plasma cTnl concentration > 0.25 ng/mL could be used to identify cardiac hemangiosarcoma in dogs with pericardia effusion (sensitivity, 81%; specificity, 100%). CONCLUSIONS AND CLINICAL RELEVANCE: The median plasma cTnl concentration was higher in dogs with cardiac hemangiosarcoma, compared with the median concentration in dogs with hemangiosarcoma at other sites, dogs with other neoplasms, and dogs with pericardial effusion not caused by hemangiosarcoma. The plasma cTnl concentration may be used to identify cardiac involvement in dogs with hemangiosarcoma and to identify cardiac hemangiosarcoma in dogs with pericardial effusion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20919846/