Peer-reviewed veterinary case report
Bone marrow concentrate vs RIA for healing dog bone nonunions
By Lam, Kenrick et al.·Published in Injury·2024·Department of Orthopaedic Surgery, United States·View original on PubMed →
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Original publication title: Comparison of reamer irrigator aspirator (RIA) suspension versus bone marrow aspirate concentrate (BMC) for percutaneous treatment of long bone nonunions-A preclinical canine model.
- Species:
- dog
Plain-English summary
A group of dogs with broken bones that weren't healing properly (nonunions) were treated with either bone marrow aspirate concentrate (BMC) or a reamer irrigator aspirator (RIA) suspension to see which helped heal better. After eight weeks, the dogs treated with BMC showed more signs of bone healing, including better formation of new bone tissue. Both treatments were safe, but BMC was more effective in promoting healing at the injury sites.
People also search for: dog broken bone treatment · nonunion bone healing in dogs · BMC for dog bone repair
Abstract
OBJECTIVE: To compare the bone healing effects of percutaneously delivered bone marrow aspirate concentrate (BMC) versus reamer irrigator aspirator (RIA) suspension in a validated preclinical canine ulnar nonunion model. We hypothesized that BMC would be superior to RIA in inducing bone formation across a nonunion site after percutaneous application. The null hypothesis was that BMC and RIA would be equivalent. METHODS: A bilateral ulnar nonunion model (n= 6; 3 matched pairs) was created. Eight weeks after segmental ulnar ostectomy, RIA from the ipsilateral femur and BMC from the proximal humerus were harvested and percutaneously administered into either the left or right ulnar defect. The same volume (3 ml) of RIA suspension and BMC were applied on each side. Eight weeks after treatment, the dogs were euthanized, and the nonunions were evaluated using radiographic, biomechanical, and histologic assessments. RESULTS: All dogs survived for the intended study duration, formed radiographic nonunions 8 weeks after segmental ulnar ostectomy, and underwent the assigned percutaneous treatment. Radiographic and macroscopic assessments of bone healing at the defect sites revealed superior bridging-callous formation in BMC-treated nonunions. Histologic analyses revealed greater amount of bony bridging and callous formation in the BMC group. Biomechanical testing of the treated nonunions did not reveal any significant differences. CONCLUSION: Bone marrow aspirate concentrate (BMC) had important advantages over Reamer Irrigator Aspirator (RIA) suspension for percutaneous augmentation of bone healing in a validated preclinical canine ulnar nonunion model based on clinically relevant radiographic and histologic measures of bone formation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38701674/