Peer-reviewed veterinary case report
Sentinel lymph node mapping changes after mast cell tumor surgery
By Buirkle, Corinne L et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2025·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Comparison of sentinel lymph node mapping patterns before and after surgical excision of mast cell tumors in dogs using indirect lymphography: A prospective clinical study.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors (MCTs) underwent surgery to remove the tumors, and researchers wanted to see how this affected the lymph nodes that drain from the tumor site. They found that while the lymphatic drainage patterns changed after surgery, most dogs still had identifiable sentinel lymph nodes (the first nodes that cancer might spread to). In some cases, the same lymph nodes were found before and after surgery, but in others, there were differences. This means that vets should be careful when interpreting lymph node results after surgery for MCTs, as the surgery can affect which nodes are detected.
People also search for: dog mast cell tumor surgery · sentinel lymph node mapping in dogs · changes after dog tumor removal
Abstract
Sentinel lymph node (SLN) mapping has been shown to be important for staging in dogs with mast cell tumors (MCTs). Despite this, many patients are referred to an oncologist after surgical intervention has been carried out. It is unknown whether lymphatic drainage patterns are altered by surgery and whether postoperative SLN mapping can be reliably conducted. The objective of this study was to compare lymphatic drainage patterns from MCT sites before and after surgical removal to determine whether the SLN changes following tumor excision. Twenty-nine client-owned dogs with 31 cytologically diagnosed MCTs were prospectively enrolled, with 14 dogs (N = 15 MCTs) completing the study. Preoperative SLN mapping was conducted using radiographic indirect lymphography (IL). Water-soluble iodinated contrast (WIC) medium was injected peritumorally using a 4-quadrant technique and digital radiography was then used to assess lymphatic drainage patterns. Orthogonal projections were obtained every 1 to 2 min until the SLN was visualized, up to 20 min post-injection. Dogs were re-evaluated 2 to 5 wk postoperatively and radiographic IL was carried out again using the same protocol as previously described with WIC injected around the surgical scar line in a 4-quadrant technique. An SLN was identified for 15 MCTs in 14 dogs preoperatively and in 13/15 MCTs postoperatively. Sixteen dogs with 16 MCTs did not have postoperative lymphography and did not complete the study. Agreement between preoperative and postoperative SLNs was a complete match in 7/15 MCTs, a partial match in 5/15 MCTs, and no match in 3/15 MCTs. A negative IL study was obtained in 2/15 MCTs postoperatively. Complete agreement between preoperative and postoperative SLN identification was detected in 46.7% of cases and there was no agreement in 20% of cases. Surgical intervention did not change the time to SLN identification when carrying out radiographic IL. Thus, surgical removal of MCTs affects lymphatic drainage and can alter the SLN(s) detected. Clinicians should be aware of this finding and interpret results of postoperative lymph node staging with caution.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39744465/