Peer-reviewed veterinary case report
Serum amyloid A vs C-reactive protein for inflammation in dogs
By Christensen, Michelle B et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2014·Department of Veterinary Clinical and Animal Sciences, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs.
- Species:
- dog
Plain-English summary
A study looked at two blood tests, serum amyloid A (SAA) and C-reactive protein (CRP), to see which one is better at detecting inflammation in dogs. Researchers found that both tests showed higher levels in dogs with inflammation compared to healthy dogs, but SAA was more effective overall. This means that if your dog is showing signs of illness, like fever or lethargy, your vet might use these tests to help determine if there’s inflammation present. SAA could provide more accurate results than CRP in these situations.
People also search for: dog inflammation blood test · SAA vs CRP in dogs · why is my dog lethargic and feverish
Abstract
The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24489396/