Peer-reviewed veterinary case report
Shelf-stable vs regular blood products for dog shock treatment
By Edwards, Thomas H et al.·Published in The journal of trauma and acute care surgery·2024·From the US Army Institute of Surgical Research (T.H.E., United States·View original on PubMed →
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Original publication title: Comparison of shelf-stable and conventional resuscitation products in a canine model of hemorrhagic shock.
- Species:
- dog
Plain-English summary
A group of adult dogs was put into a state of severe shock by losing a significant amount of blood. They were then treated with different types of resuscitation products, including fresh frozen plasma and a new shelf-stable blood product. The dogs that received fresh frozen plasma and packed red blood cells showed better recovery, with higher blood pressure readings compared to those treated with conventional whole blood. While some dogs experienced a temporary increase in kidney values with the new products, overall, the shelf-stable options performed well in helping the dogs recover from shock.
People also search for: dog hemorrhagic shock treatment · shelf-stable blood products for dogs · canine blood transfusion options
Abstract
BACKGROUND: Treatment of severe hemorrhagic shock typically involves hemostatic resuscitation with blood products. However, logistical constraints often hamper the wide distribution of commonly used blood products like whole blood. Shelf-stable blood products and blood substitutes are poised to be able to effectively resuscitate individuals in hemorrhagic shock when more conventional blood products are not readily available. METHODS: Purpose-bred adult dogs (n = 6) were anesthetized, instrumented, and subjected to hemorrhagic shock (mean arterial pressure <50 mm Hg or 40% blood volume loss). Then each dog was resuscitated with one of five resuscitation products: (1) lactated ringers solution and hetastarch (LRS/Heta), (2) canine chilled whole blood (CWB), (3) fresh frozen plasma (FFP) and packed red blood cells (pRBC), (4) canine freeze-dried plasma (FDP) and hemoglobin-based oxygen carrier (HBOC), or (5) HBOC/FDP and canine lyophilized platelets (LyoPLT). Each dog was allowed to recover after the hemorrhage resuscitation event and was then subjected to another hemorrhage event and resuscitated with a different product until each dog was resuscitated with each product. RESULTS: At the time when animals were determined to be out of shock as defined by a shock index <1, mean arterial pressure (mmHg) values (mean ± standard error) were higher for FFP/pRBC (n = 5, 83.7 ± 4.5) and FDP/HBOC+LyoPLT (n = 4, 87.8 ± 2.1) as compared with WB (n = 4, 66.0 ± 13.1). A transient increase in creatinine was seen in dogs resuscitated with HBOC and FDP. Albumin and base excess increased in dogs resuscitated with HBOC and FDP products compared with LRS/heta and CWB ( p < 0.01). CONCLUSION: Combinations of shelf-stable blood products compared favorably to canine CWB for resolution of shock. Further research is needed to ascertain the reliability and efficacy of these shelf-stable combinations of products in other models of hemorrhage that include a component of tissue damage as well as naturally occurring trauma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38706102/