Peer-reviewed veterinary case report
Comparing terazosin and prazosin side effects in dogs with urinary
By Haagsman, A N et al.·Published in The Veterinary record·2013·Faculty of Veterinary Medicine, Netherlands·View original on PubMed →
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Original publication title: Comparison of terazosin and prazosin for treatment of vesico-urethral reflex dyssynergia in dogs.
- Species:
- dog
Plain-English summary
Nineteen dogs with urinary problems, specifically vesico-urethral reflex dyssynergia (VURD), were treated with either prazosin or terazosin to see which worked better and had fewer side effects. Both medications helped about 60-64% of the dogs, but those on terazosin experienced more side effects than those on prazosin. Labradors and dogs that were surgically castrated had better survival rates compared to other breeds and those that were chemically castrated. Overall, prazosin seemed to be the safer option for treating this condition in dogs.
People also search for: dog urinary problems treatment · prazosin for dogs · terazosin side effects in dogs
Abstract
Nineteen dogs with vesico-urethral reflex dyssynergia (VURD) were treated with prazosin or terazosin 0.5 mg/kg twice daily to compare efficacy and side effects. Dogs were referred because of signs of (partial) urethral obstruction. Physical examination, abdominal ultrasonography, urinalysis and a radiographic contrast study of bladder and urethra (urethrocystography) were routinely performed. If no mechanical causes of obstruction or disease of the distal urinary tract were observed, the diagnosis VURD was presumed and the dogs were included in our study. Follow-up information was obtained from owners or referring veterinarians. Significantly more side effects were seen in the dogs treated with terazosin (n=14; 93 per cent) compared with the dogs treated with prazosin (n=5; 20 per cent; P=0.002). Effects of the treatment were comparable between prazosin and terazosin. Labradors and dogs that were castrated surgically had a significant better survival (P<0.01) compared with other breeds and animals that were castrated chemically. There was a moderate to good effect in 60 per cent of the dogs treated with prazosin, and in 64 per cent of the dogs treated with terazosin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23784060/