Peer-reviewed veterinary case report
Anesthetic effects of alfaxalone vs propofol in cats
By Tamura, Jun et al.·Published in The Journal of veterinary medical science·2021·Rakuno Gakuen University, Japan·View original on PubMed →
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Original publication title: Comparison of the anesthetic effects between 5 mg/kg of alfaxalone and 10 mg/kg of propofol administered intravenously in cats.
- Species:
- cat
Plain-English summary
Six cats were given either alfaxalone or propofol through an IV to see which anesthetic worked better. Both medications quickly put the cats to sleep without causing breathing issues, but the cats given propofol experienced more temporary low oxygen levels. After waking up, the cats treated with alfaxalone showed more side effects like unsteady walking and muscle shaking compared to those that received propofol. Overall, while both anesthetics were effective, alfaxalone had more noticeable recovery side effects.
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Abstract
To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without premedication, either alfaxalone (5 mg/kg) or propofol (10 mg/kg) was administered intravenously over 120 sec in 6 cats. Each cat received the alternate treatment at least a 7-day interval. Anesthetic effects (tolerance of intubation, behavior changes and neurodepressive score) and physiological parameters were evaluated. Both treatments produced a rapid loss of consciousness, no apnea, and physiological parameters were maintained within clinically acceptable ranges apart from transient hypoxemia. The degree of hypoxemia was greater after the propofol treatment compared with the alfaxalone treatment. During the recovery period, more adverse events (ataxia, muscular tremors) were observed after the alfaxalone treatment compared with the propofol treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33431725/