Peer-reviewed veterinary case report
Effects of anastrazole and tamoxifen on dog prostate and semen
By Gonzalez, G et al.·Published in Reproduction in domestic animals = Zuchthygiene·2009·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Comparison of the effect of the aromatase inhibitor, anastrazole, to the antioestrogen, tamoxifen citrate, on canine prostate and semen.
- Species:
- dog
Plain-English summary
A group of 40 healthy dogs, some with benign prostate hyperplasia (BPH), were treated with either anastrazole or tamoxifen to see which medication worked better for reducing prostate size. After 60 days, the dogs receiving tamoxifen showed a significant decrease in prostate volume, while those on anastrazole also had a reduction, but it was less pronounced. Importantly, anastrazole did not affect libido or sperm quality, making it a promising option for managing BPH in dogs without causing side effects.
People also search for: dog prostate problems treatment · anastrazole for dogs · tamoxifen for dog prostate enlargement · benign prostatic hyperplasia in dogs
Abstract
This study compared the efficiency of the aromatase inhibitor, anastrazole, with the antioestrogenic receptor blocker, tamoxifen, on normal (NRL) and hyperplastic prostate glands. Forty healthy dogs were classified as NRL (n = 18) or abnormal (ABN) with benign prostate hyperplasia (n = 22). The dogs were randomly assigned to one of the following six groups, treated for 60 days; oral placebo for normal (NRL-PLC; n = 6) and abnormal (ABN-PLC; n = 6), oral anastrazole 0.25-1 mg/day, for normal (NRL-ANZ, n = 6) and abnormal (ABN-ANZ, n = 8) and oral tamoxifen citrate 2.5-10 mg/day for normal (NRL-TMX; n = 6) and abnormal (ABN-TMX; n = 8) dogs. The dogs were evaluated before treatment and then monthly for 4 months. At the end of the treatment, the prostatic volume decreased by 28.5 +/- 4.3%, 21.6 +/- 6.3% and 0.7 +/- 1.0% in the ABN-TMX, ABN-ANZ and ABN-PLC (p < 0.01), respectively. From then on, prostatic volume began to increase without reaching pre-treatment values at the end of the study. In the ABN animals, there were no differences for this parameter between ANZ and TMX treatment (p > 0.1), whereas in the NRL animals ANZ produced a less pronounced decrease (p < 0.05), libido, testicular consistency and scrotal diameter decreased during treatment in the TMX group (p > 0.05). These parameters and sperm volume, count, motility and morphological abnormalities remained unaltered throughout the study in the ANZ and PLC groups (p > 0.05). There were no haematological nor biochemical side effects. Anastrazole might offer a safe and effective alternative for the medical management of dogs with benign prostatic hyperplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19754594/