Peer-reviewed veterinary case report
Pain relief comparison of firocoxib carprofen and vedaprofen in dogs
By Hazewinkel, Herman A W et al.·Published in Research in veterinary science·2008·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.
- Species:
- dog
Plain-English summary
A group of eight dogs with arthritis caused by sodium urate crystals were treated with firocoxib, carprofen, or vedaprofen to see which pain relief medication worked best. The dogs showed significant improvement in their ability to bear weight and had lower lameness scores after receiving firocoxib compared to the other treatments and a placebo. Specifically, firocoxib was more effective at reducing pain and improving movement three and seven hours after treatment. This suggests that firocoxib may be a better option for managing arthritis pain in dogs.
People also search for: dog arthritis pain relief · firocoxib for dogs · carprofen vs firocoxib for arthritis
Abstract
A randomized, placebo-controlled, four-period cross-over laboratory study involving eight dogs was conducted to confirm the effective analgesic dose of firocoxib, a selective COX-2 inhibitor, in a synovitis model of arthritis. Firocoxib was compared to vedaprofen and carprofen, and the effect, defined as a change in weight bearing measured via peak ground reaction, was evaluated at treatment dose levels. A lameness score on a five point scale was also assigned to the affected limb. Peak vertical ground reaction force was considered to be the most relevant measurement in this study. The firocoxib treatment group performed significantly better than placebo at the 3 h post-treatment time point and significantly better than placebo and carprofen at the 7 h post-treatment time point. Improvement in lameness score was also significantly better in the dogs treated with firocoxib than placebo and carprofen at both the 3 and 7 h post-treatment time points.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17408711/