Peer-reviewed veterinary case report
Pain relief and blood tests after jaw surgery in dogs with cancer
By Martins, Teresinha L et al.·Published in American journal of veterinary research·2010·Department of Surgery, Brazil·View original on PubMed →
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Original publication title: Comparison of the effects of tramadol, codeine, and ketoprofen alone or in combination on postoperative pain and on concentrations of blood glucose, serum cortisol, and serum interleukin-6 in dogs undergoing maxillectomy or mandibulectomy.
- Species:
- dog
Plain-English summary
A group of 42 dogs with oral tumors underwent surgery to remove part of their jaw and received different pain medications afterward. The medications included tramadol, codeine, and ketoprofen, either alone or in combination. All treatments effectively managed pain without causing serious side effects, although some dogs given codeine and ketoprofen experienced mild sedation. Blood sugar levels increased slightly after treatment, but other health markers remained stable. Overall, the pain relief was successful, helping the dogs recover comfortably after surgery.
People also search for: dog oral tumor surgery pain relief · tramadol codeine ketoprofen for dogs · postoperative care for dogs after jaw surgery
Abstract
OBJECTIVE: To compare analgesic effects of tramadol, codeine, and ketoprofen administered alone and in combination and their effects on concentrations of blood glucose, serum cortisol, and serum interleukin (IL)-6 in dogs undergoing maxillectomy or mandibulectomy. ANIMALS: 42 dogs with oral neoplasms. PROCEDURES: 30 minutes before the end of surgery, dogs received SC injections of tramadol (2 mg/kg), codeine (2 mg/kg), ketoprofen (2 mg/kg), tramadol+ketoprofen, or codeine+ketoprofen (at the aforementioned dosages). Physiologic variables, analgesia, and sedation were measured before (baseline) and 1, 2, 3, 4, 5, and 24 hours after surgery. Blood glucose, serum cortisol, and serum IL-6 concentrations were measured 1, 3, 5, and 24 hours after administration of analgesics. RESULTS: All treatments provided adequate postoperative analgesia. Significant increases in mean+/-SD blood glucose concentrations were detected in dogs receiving tramadol (96+/-14 mg/dL), codeine (120+/-66 mg/dL and 96+/-21 mg/dL), ketoprofen (105+/-22 mg/dL), and codeine+ketoprofen (104+/-16 mg/dL) at 5, 1 and 3, 5, and 3 hours after analgesic administration, respectively, compared with preoperative (baseline) values. There were no significant changes in physiologic variables, serum IL-6 concentrations, or serum cortisol concentrations. Dogs administered codeine+ketoprofen had light but significant sedation at 4, 5, and 24 hours. CONCLUSIONS AND CLINICAL RELEVANCE: Opioids alone or in combination with an NSAID promoted analgesia without adverse effects during the 24-hour postoperative period in dogs undergoing maxillectomy or mandibulectomy for removal of oral neoplasms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20807140/