Peer-reviewed veterinary case report
Comparing cyclosporine and leflunomide for dachshund colorectal polyps
By Tani, Akiyoshi et al.·Published in The Journal of veterinary medical science·2020·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Comparison of the efficacy of cyclosporine and leflunomide in treating inflammatory colorectal polyps in miniature dachshunds.
- Species:
- dog
Plain-English summary
A group of miniature dachshunds with inflammatory colorectal polyps (ICRPs) were treated with either cyclosporine or leflunomide to see which worked better. The dogs treated with leflunomide had a higher success rate, but both treatments had similar recovery times and chances of the polyps coming back. Some dogs on leflunomide experienced side effects like gastrointestinal issues, while none on cyclosporine had any problems. Overall, both medications were effective, but leflunomide showed better results in this case.
People also search for: dachshund inflammatory bowel disease treatment · dog colorectal polyps medication · leflunomide side effects in dogs
Abstract
Inflammatory colorectal polyps (ICRPs) are frequently observed in miniature dachshunds in Japan and treated by prednisolone and immunosuppressive drugs such as cyclosporine and leflunomide. The purpose of this retrospective study was to compare the treatment efficacy, such as response rate, response interval, recurrence rate, and adverse events between cyclosporine and leflunomide. While the response rates were significantly higher in dogs treated with leflunomide, no significant differences were observed in the response interval or recurrence rate. Two of the 11 dogs treated with leflunomide showed hematological or gastrointestinal adverse events, while no dog treated with cyclosporine showed any adverse events. A case-controlled prospective study to compare the treatment efficacy of leflunomide with that of cyclosporine should be conducted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32062634/