Peer-reviewed veterinary case report
How fast Bravecto and Simparica TRIO kill ticks on dogs
By Reif, Kathryn E et al.·Published in Parasites & vectors·2025·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Comparison of the initial and residual speed of Amblyomma americanum kill on dogs treated with a single dose of Bravecto® Chew (25 mg/kg fluralaner) or Simparica TRIO® (1.2 mg/kg sarolaner, 24 µg/kg moxidectin, 5 mg/kg pyrantel).
- Species:
- dog
Plain-English summary
A group of dogs with tick infestations were treated with either Bravecto (a chewable medication) or Simparica TRIO (a combination treatment) to see which worked better at killing ticks. The dogs treated with Bravecto showed significant tick control within just 8 hours, reaching nearly complete control by 12 hours. In contrast, the Simparica TRIO treatment took longer to show effectiveness, with significant control starting at 24 hours. Overall, Bravecto was faster and more effective at controlling the ticks over several weeks without causing any side effects.
People also search for: dog tick treatment · Bravecto vs Simparica TRIO · how fast does Bravecto work for ticks · dog tick prevention products
Abstract
BACKGROUND: To manage tick infestations and reduce tick-borne pathogen transmission risk to dogs, compliant administration of a fast-acting ectoparasiticide is necessary. Isoxazoline-containing ectoparasiticide products provide systemic whole-body coverage; however, differences in tick kill have been observed between products and these differences may be more pronounced when controlling common dose-limiting tick species such as Amblyomma americanum. METHODS: Dogs were ranked by tick carrying capacity, randomly allocated to one of three treatment groups, and administered Bravecto® Chews (minimum 25 mg/kg fluralaner), Simparica TRIO® (minimum 1.2 mg/kg sarolaner, 24 µg/kg moxidectin, 5 mg/kg pyrantel), or no treatment. Dogs were infested with approximately 50 unfed adult (25 female, 25 male) A. americanum on days -2, 21, 28, and 35. Live tick counts were performed at 8, 12, 24, 48, and 72 h post-treatment (day 0) and post-infestation on days 21, 28, and 35. At each tick count timepoint, product efficacy was determined by comparing geometric mean live tick counts for each product-treated group to the untreated group and a linear mixed model was used for between-group comparisons. RESULTS: Compared with untreated dogs, significant control of existing A. americanum infestations began by 8 h post-treatment (81.6%) and reached 98.0% control by 12-h for Bravecto®-treated dogs. In comparison, significant control for Simparica TRIO®-treated dogs began by 24 h post-treatment (97.7%). When reinfested on day 21, A. americanum infestations were controlled more quickly for Bravecto® compared with Simparica TRIO®-treated dogs at 12 h (efficacy 95.3% versus 25.5%, P < 0.001) and 24 h (efficacy 99.7% versus 70.9%, P < 0.001) post-infestation. Similarly, when reinfested on day 28, faster A. americanum control occurred for Bravecto® compared with Simparica TRIO®-treated dogs at 12 h (efficacy 87.9% versus 18.3%, P < 0.001) and at 24 h (99.2% versus 59.3%, P < 0.001) post-infestation. Finally, when reinfested on day 35, time to ≥ 90% efficacy was achieved by 48 h for Bravecto®-treated dogs compared with 72 h post-infestation for Simparica TRIO®-treated dogs. Both products performed within label indications and no treatment-related adverse reactions occurred during the study. CONCLUSIONS: Amblyomma americanum infestations are controlled more quickly immediately upon treatment and at 21, 28, and 35 days post-treatment for Bravecto® compared with Simparica TRIO®-treated dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40119355/