Peer-reviewed veterinary case report
Intranasal Bordetella vaccine cuts coughing and bacteria in dogs
By Davis, Randy et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2007·Schering Plough Animal Health, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Comparison of the mucosal immune response in dogs vaccinated with either an intranasal avirulent live culture or a subcutaneous antigen extract vaccine of Bordetella bronchiseptica.
- Species:
- dog
Plain-English summary
A group of healthy dogs with low immunity to Bordetella bronchiseptica (a bacteria that can cause kennel cough) were vaccinated either through their nose with a live vaccine or under the skin with an antigen extract vaccine. The dogs that received the intranasal vaccine developed strong immunity in their noses, which helped them fight off the bacteria better when exposed later. These dogs had much less coughing and spread fewer germs compared to those who received the other vaccines. The intranasal vaccine proved to be more effective in protecting against kennel cough.
People also search for: dog kennel cough vaccine · Bordetella vaccine effectiveness · why is my dog coughing after vaccination
Abstract
Healthy dogs with low antibody titer to Bordetella bronchiseptica were vaccinated intranasally with an avirulent live vaccine, subcutaneously with an antigen extract vaccine, or subcutaneously and intranasally with a placebo. Intranasally vaccinated dogs developed B. bronchiseptica-specific IgA titers in nasal secretions that remained at high levels until the end of the study; dogs vaccinated subcutaneously with the antigen extract or placebo did not develop measurable antigen-specific IgA titers in nasal secretions. Dogs were challenged with virulent live B. bronchiseptica 63 days after vaccination. Intranasally vaccinated dogs had significantly lower cough scores (P < or =.0058) and shed significantly fewer challenge organisms (P <.0001) than dogs in either of the other groups. Cough scores of subcutaneously vaccinated dogs were not significantly different from placebo-vaccinated dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17447223/