Peer-reviewed veterinary case report
Antibody tests compared for diagnosing autoimmune skin diseases
By Pérez, José et al.·Published in Veterinary dermatology·2002·Departamento de Anatomí, Spain·View original on PubMed →
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Original publication title: Comparison of three monoclonal and three polyclonal antibodies in the immunohistochemical diagnosis of canine autoimmune skin diseases.
- Species:
- dog
Plain-English summary
A group of dogs with autoimmune skin diseases, including pemphigus and discoid lupus erythematosus, had skin biopsies taken to help diagnose their conditions. Researchers tested different types of antibodies to see which ones worked best for identifying these diseases. They found that one specific antibody, CA4E7, was particularly effective, showing high accuracy in diagnosing pemphigus and lupus while causing less background interference. This suggests that using the CA4E7 antibody could improve how veterinarians diagnose these skin issues in dogs.
People also search for: dog autoimmune skin disease diagnosis · pemphigus in dogs treatment · discoid lupus erythematosus in dogs symptoms
Abstract
The aim of this study was to evaluate the utility of three monoclonal antibodies (mAbs), and two anticanine IgG and one anticanine IgM polyclonal antibodies (pAbs) for the immunohistochemical diagnosis of canine autoimmune skin diseases. Skin biopsies from 11 cases of pemphigus (7 foliaceus, 3 vulgaris and 1 erythematosus), 12 cases of discoid lupus erythematosus (DLE) and 12 cases of chronic hyperplasic dermatitis were used. The CA4E7 mAb (IgG1 + IgG2) showed similar sensitivity, but higher specificity and lower background than the two anti-IgG pAbs for the immunohistochemical diagnosis of pemphigus and DLE. The CA4F1 mAb (IgG2) and CA3H1 mAb (IgG2) showed moderate and low interepithelial reactivity, respectively, in autoimmune skin diseases, but strong staining of the cytoplasm of plasma cells of the inflammatory infiltrates. These results suggest that the CA4E7 mAb may be valuable in the immunohistochemical diagnosis of such disorders.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12358605/