Peer-reviewed veterinary case report
Comparison of tuberculin activity using the interferon-gamma assay for the diagnosis of bovine tuberculosis.
- Journal:
- The Veterinary record
- Year:
- 2010
- Authors:
- Schiller, I et al.
- Affiliation:
- Prionics
Abstract
In this study, interferon-gamma (IFN-gamma) responses in whole blood cultures stimulated with tuberculins from different sources were compared with regard to their diagnostic reliability in cattle experimentally and naturally infected with Mycobacterium bovis. The IFN-gamma responses to different concentrations of purified protein derivatives (PPDs) from M bovis and Mycobacterium avium were quantified. Significant differences (P<0.05) between sources and concentrations of PPDs used for stimulation were detected, indicating a need for standardisation of PPDs used in the IFN-gamma assay. Additionally, a tool named'relative potency 30' that allows rapid comparison of batches and sources of PPDs was defined.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20802185/