Peer-reviewed veterinary case report
Comparing two buprenorphine types given by mouth in cats
By Bortolami, Elisa et al.·Published in Journal of feline medicine and surgery·2012·University of Bristol, United Kingdom·View original on PubMed →
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Original publication title: Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route.
- Species:
- cat
Plain-English summary
Twelve cats were given two different forms of buprenorphine, a pain medication, through their mouths to see how well they tolerated it compared to a sugar solution. The study found that while the cats had no issues with vomiting or changes in behavior, they found it easier to take the sugar solution than the buprenorphine. However, both medications were generally well-tolerated, and the cats showed no significant side effects. This suggests that buprenorphine can be administered safely in this way, making it a viable option for managing pain in cats.
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Abstract
This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22403414/