Peer-reviewed veterinary case report
Comparing treatments for atopic dermatitis in beagle dogs
By Marsella, Rosanna et al.·Published in Veterinary dermatology·2020·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Comparison of various treatment options for canine atopic dermatitis: a blinded, randomized, controlled study in a colony of research atopic beagle dogs.
- Species:
- dog
Plain-English summary
Nineteen beagle dogs with atopic dermatitis (a skin allergy condition) were treated with different medications to see which worked best for their itchy skin and overall skin health. The dogs received either oclacitinib, ciclosporin, lokivetmab, prednisone, or no treatment for four weeks while being exposed to allergens. The results showed that oclacitinib and lokivetmab helped improve skin barrier function and reduced flare-ups, while prednisone also provided some relief in the first two weeks. Overall, lokivetmab was particularly effective in preventing flare-ups when given before exposure to allergens, making it a promising option for managing this condition.
People also search for: dog itching treatment · atopic dermatitis medication for dogs · lokivetmab for dog allergies
Abstract
BACKGROUND: No study has directly compared the various treatment options for canine atopic dermatitis and their effects on skin barrier. HYPOTHESIS/OBJECTIVES: To compare prednisone, oclacitinib, ciclosporin and lokivetmab treatment of atopic dermatitis. ANIMALS: Nineteen atopic beagle dogs. METHODS AND MATERIALS: Controlled, blinded study. Dogs were challenged with allergen twice weekly and randomized to oclacitinib, ciclosporin, lokivetmab, prednisone or no treatment for four weeks. Dermatitis and pruritus were assessed at baseline and after each challenge. Transepidermal water loss (TEWL) and hydration were measured at baseline, Day (D)14 and D28 (pinnae, axilla, groin). Area under the curve (AUC) was calculated for Canine Atopic Dermatitis Extent and Severity Index, 3rd iteration (CADESI-03), pruritus, TEWL and hydration. For CADESI, the AUC of the first two weeks was compared to that of the last two weeks. RESULTS: For CADESI, restricted maximum-likelihood ANOVA showed effect of time (P = 0034) and group x time interaction (P = 0.0169). In the first two weeks, prednisone and oclacitinib were significantly lower than controls (P = 0.019 and P = 0.015, respectively). Lokivetmab prevented flares. Due to variability, no significance differences in pruritus were observed among groups. The TEWL increased with time in controls (P = 0.0237) and ciclosporin (P = 0.04, axilla, D28 versus D0) but not in the oclacitinib and lokivetmab groups. CADESI-03 correlated with TEWL (P = 0.0043) and pruritus (P = 0.0283). Hydration did not correlate with any parameters. Hydration decreased in controls and prednisone group (axilla, D14 versus D0, P = 0.004 and P = 0.027, respectively). AUC for hydration, over time, was higher for lokivetmab and oclacitinib than controls (P = 0.014 and P = 0.04, respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: Lokivetmab prevented flares when given before challenge. Oclacitinib and lokivetmab have some positive effects on skin barrier parameters.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32301565/