Peer-reviewed veterinary case report
Can rabies vaccine be safely given with common dog combo vaccines?
By Thibault, Jean-Christophe et al.·Published in Comparative immunology, microbiology and infectious diseases·2022·JC&P Life Science Partner, France·View original on PubMed →
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Original publication title: Compatibility between a rabies vaccine and two canine combined vaccines against canine distemper, adenovirosis, parvovirosis, parainfluenza virus disease and leptospirosis, with or without canine coronavirus.
- Species:
- dog
Plain-English summary
A group of dogs was vaccinated with a rabies vaccine alongside two different combination vaccines that protect against several diseases, including canine distemper and parvovirus. After two weeks, all the dogs showed a strong immune response to the rabies vaccine, and 100% of the puppies also developed immunity to the other diseases covered by the combo vaccines. This means that giving these vaccines together is safe and effective, helping ensure that dogs are fully protected without needing separate visits.
People also search for: dog rabies vaccine safety · canine distemper vaccine combination · puppy vaccination schedule
Abstract
In many countries, vaccination programs still require dogs to be vaccinated against rabies in addition to Canine distemper virus (CDV), adenovirus (CAV), parvovirus (CPV), parainfluenza virus (CPiV), Leptospira (L) or Canine coronavirus (CCV= Cv). Few vaccines containing all these antigens are commercially available and, unless compatibility between the vaccines was demonstrated, concurrent administration of a DAPPi-L(Cv) vaccine and a vaccine against rabies should not be recommended. This may be of concern for practitioners who wish to vaccinate dogs with all components on the same day. This study aimed at evaluating immunological compatibility between a monovalent rabies vaccine (Rabisin™) and two large combination vaccines against CDV, CAV, CPV, CPiV with 2 leptospira components +Cv (Recombitek® C6/Cv) or with 4 Leptospira components (Recombitek® C8), when injected concomitantly at two separate injection sites. Fourteen days after administration of the rabies vaccine, with or without concomitant administration of combo vaccines, all dogs had seroconverted against rabies and maintained protective titers over the duration of the study. In addition, 100% of the puppies vaccinated with one or the other combo vaccines seroconverted against CDV, CAV, CPV, CPiV (CCV) and Leptospira, whatever the vaccination group. Lack of immunological interference between Rabisin™ and all components of the Recombitek® C6/Cv or Recombitek® C8 Combo vaccines was demonstrated by non-inferiority analysis, except for CDV in the Recombitek®C8+ Rabisin™ group. Based on these results, a concomitant administration of Rabisin™ with Recombitek® C6/Cv or Recombitek® C8 can be recommended in daily practice, which can be essential for facilitating vaccination compliance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35429805/