Peer-reviewed veterinary case report
Complete protection of cats from feline panleukopenia with new vaccine
By Yang, Songtao et al.·Published in Vaccine·2008·Military Institute of Veterinary Sciences, China·View original on PubMed →
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Original publication title: Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV.
- Species:
- cat
Plain-English summary
Ten 3-month-old cats were vaccinated against feline panleukopenia virus (FPV) using a new type of vaccine made from a modified canine virus. After receiving the vaccine and two booster shots, all the cats developed strong immunity, with their antibody levels increasing significantly. When later exposed to FPV, none of the cats showed any signs of illness or had the virus detected in their systems. This new vaccine could be a promising option for protecting cats against this serious disease.
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Abstract
Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome carrying a VP2 expression cassette. Ten 3-month-old cats were vaccinated with the recombinant virus with two boosters at 15-day intervals. All cats developed neutralizing antibodies of titers 1:16-1:32 by day 15 post-primary vaccination, increasing to 1:64-1:128 by day 45. Examination for clinical signs and viral presence, and total white blood cell counts in peripheral blood following FPV challenge, showed that all were completely protected. This recombinant virus appears to provide an effective alternative to attenuated and inactivated vaccines in immunizing cats against feline panleukopenia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18313810/