Peer-reviewed veterinary case report
Complex Evolutionary Dynamics of H5N8 Influenza A Viruses Revealed by Comprehensive Reassortment Analysis.
- Journal:
- Viruses
- Year:
- 2024
- Authors:
- Degtyarev, Egor et al.
- Affiliation:
- Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
- Species:
- bird
Abstract
Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its high pathogenicity in birds and potential for cross-species transmission. We retrieved 2359 H5N8 IAV sequences from GISAID, and filtered and analyzed 442 complete genomic sequences for reassortment events using pairwise distance deviation matrices (PDDMs) and pairwise distance correspondence plots (PDCPs). This detailed case study of specific H5N8 viruses revealed previously undescribed reassortment events, highlighting the complex evolutionary history and potential pandemic threat of H5N8 IAVs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39339881/