Peer-reviewed veterinary case report
Serum collagen XXVII protein levels in dogs with hemangiosarcoma
By Kirby, G M et al.·Published in Journal of veterinary internal medicine·2011·Department of Biomedical Sciences, Canada·View original on PubMed →
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Original publication title: Concentration of lipocalin region of collagen XXVII alpha 1 in the serum of dogs with hemangiosarcoma.
- Species:
- dog
Plain-English summary
A study found that dogs with hemangiosarcoma, a serious type of cancer, had much higher levels of a specific protein called collagen XXVII in their blood compared to healthy dogs. In fact, the protein levels were nearly ten times higher in dogs with advanced cancer. This protein could help vets diagnose hemangiosarcoma more accurately and monitor the disease after treatment, like surgery or chemotherapy. After removing the tumor, the protein levels dropped, but they increased again in some dogs if the cancer returned.
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Abstract
BACKGROUND: Hemangiosarcoma (HSA) is a common malignancy of dogs with characteristic early, aggressive metastasis. Diagnosis of HSA is challenging because of lack of sensitive and specific diagnostic tests. HYPOTHESIS: Specific proteins that are increased in serum of dogs with HSA might represent useful biomarkers of the disease. ANIMALS: Thirty-four dogs with HSA and 42 healthy dogs from the Ontario Veterinary College Teaching Hospital. METHODS: This case-control study compared serum proteins in dogs with HSA and healthy dogs. Proteins were separated by 2-dimensional difference gel electrophoresis and identified by liquid chromatography and tandem mass spectrometry. RESULTS: Western blot analysis showed that serum collagen XXVII peptide concentration in serum of dogs with large metastatic HSA burdens (1,488, 231-3,754 DU; median, minimum-maximum); was, on average, 9.5-fold higher than in healthy dogs (156; 46-2,101 DU). While concentrations for dogs with osteosarcomas (678; 124-3,251 DU), lymphomas (423; 92-2,777 DU), carcinomas (1,022; 177-3,448 DU), and inflammatory disease were also increased, values were consistently lower than those for HSA. Receiver operating characteristic curves revealed an estimated area under the curve of 83% for HSA cases whereas areas for other neoplastic and nonneoplastic diseases were nondiscriminatory. Serum collagen XXVII peptide concentration before splenectomy (1,350; 1,156-1,929 DU) was reduced after tumor removal (529; 452-562 DU) and chemotherapy but increased in 2 dogs with tumor recurrence (511-945 DU; 493-650 DU). CONCLUSIONS AND CLINICAL IMPORTANCE: Collagen XXVII peptide might be useful for diagnosis and monitoring of advanced HSA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21418324/