Peer-reviewed veterinary case report
Blood protein levels linked to uterine infection in female dogs
By Dąbrowski, Roman et al.·Published in Theriogenology·2013·Department and Clinic of Animal Reproduction·View original on PubMed →
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Original publication title: Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra.
- Species:
- dog
Plain-English summary
A female dog with pyometra, a serious infection of the uterus, was studied to see if certain blood markers could indicate inflammation. Researchers found that levels of C-reactive protein, serum amyloid A, and haptoglobin were higher in dogs with a closed-cervix form of pyometra compared to those with an open-cervix form. This suggests that measuring these markers in blood could help veterinarians monitor the severity of the condition. Treatment for pyometra typically involves surgery to remove the infected uterus, and early detection is crucial for a better outcome.
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Abstract
Pyometra is a life-threatening reproductive disorder that affects the uterus of female dogs. This study was designed to identify the possible indicators of uterine inflammation by comparing C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp) concentrations in uterine arterial and peripheral venous blood in bitches with open- and closed-cervix pyometra. CRP, SAA, and Hp concentrations were higher in bitches with closed-cervix pyometra irrespective of the site of blood collection. Higher acute-phase protein concentrations were observed in peripheral compared with uterine arterial blood in bitches with closed-cervix pyometra, whereas the levels were comparable in dogs with open-cervix pyometra. Our results indicate that mean acute-phase protein concentrations differ according to pyometra type/severity and blood source and suggest the possible use of peripheral blood levels of CRP, SAA, and Hp to monitor inflammation during the course of pyometra.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23810209/