Peer-reviewed veterinary case report
Leptin levels drop in obese cats during weight loss study
By Takashima, Satoshi et al.·Published in The Journal of veterinary medical science·2019·Joint Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Concentrations of leptin, adiponectin, and resistin in the serum of obese cats during weight loss.
- Species:
- cat
Plain-English summary
A group of six obese cats was put on a low-fat, high-fiber diet for nine weeks to help them lose weight. As the cats lost weight, their serum leptin levels (a hormone related to fat storage) decreased significantly, while levels of adiponectin and resistin (other hormones) did not change much. By the end of the study, the cats had lost enough weight to show a clear drop in leptin levels, which suggests that this hormone is closely linked to obesity in cats. This diet helped the cats lose weight effectively, which is important for their overall health.
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Abstract
We monitored changes in serum leptin, adiponectin, and resistin concentrations in obese cats during weight loss. Six naturally developed obese cats were fed low-fat, high-fiber dry food during a 9-week experimental period. Serum leptin, adiponectin, and resistin concentrations were measured at week 0, 4, 8, and 9. Body weight became significantly lower week 4 onward than that at week 0 (P<0.05 or 0.01). At week 9, serum leptin concentrations were significantly lower than those at week 0 (P<0.05). Contrarily, serum adiponectin and resistin concentrations did not significantly differ within the 9 weeks. While serum leptin levels were strongly positively correlated with body weight (r=0.923, P<0.001), serum adiponectin levels were moderately negatively correlated with it (r=-0.529, P<0.01), with serum resistin having a no correlation with body weight. Serum leptin levels might be more closely related with pathogenesis of adiposity than serum adiponectin or resistin in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31366817/