Peer-reviewed veterinary case report
Intranasal plus injection vaccine protects kittens better from feline
By Reagan, K L et al.·Published in Veterinary journal (London, England : 1997)·2014·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Concurrent administration of an intranasal vaccine containing feline herpesvirus-1 (FHV-1) with a parenteral vaccine containing FHV-1 is superior to parenteral vaccination alone in an acute FHV-1 challenge model.
- Species:
- cat
Plain-English summary
A group of kittens was tested to see if getting two types of vaccines for feline herpesvirus-1 (FHV-1) at the same time would work better than just one. The kittens that received both the intranasal and subcutaneous vaccines showed significantly less severe illness and had lower levels of the virus in their throats compared to those who only got the subcutaneous vaccine. This suggests that giving both vaccines together offers better protection against FHV-1.
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Abstract
The administration of intranasal (IN) or subcutaneous (SC) vaccines containing modified live feline herpesvirus 1 (FHV-1) offers some level of protection against FHV-1 challenge, but relative efficacy is <100%. In this study, clinical signs and viral shedding in kittens were compared among three groups: (1) kittens vaccinated concurrently with IN and SC vaccines containing FHV-1 (Group 1, n = 8); (2) kittens vaccinated with a SC FHV-1 vaccine alone (Group 2, n = 8), and (3) unvaccinated control kittens (Group 3, n = 8). All kittens were FHV-1 naïve at enrolment, and challenge with a virulent strain of FHV-1 was performed 1 week after vaccination. Daily clinical signs and pharyngeal FHV-1 shedding were recorded over a 21-day infection period. Overall, kittens in Group 1 had significantly less severe clinical illness than those in Group 2 (P < 0.05). Additionally, significantly less FHV-1 DNA was detected on pharyngeal swabs from kittens in Group 1 compared to those in Group 2 (P < 0.001). Concomitant administration of IN and SC FHV-1 vaccines was superior to administration of the SC FHV-1 vaccine alone in this challenge model of FHV-1 naïve kittens.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24873978/