Peer-reviewed veterinary case report
Gel improves electrochemotherapy for small tumors with needle
By Suzuki, Daniela O H et al.·Published in Artificial organs·2016·Institute of Biomedical Engineering, Brazil·View original on PubMed →
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Original publication title: Conductive Gel Increases the Small Tumor Treatment With Electrochemotherapy Using Needle Electrodes.
- Species:
- dog
Plain-English summary
A dog with squamous cell carcinoma (a type of skin cancer) had superficial tumors treated using a method called electrochemotherapy, which combines chemotherapy with electric fields. Researchers found that using conductive gel with needle electrodes improved the treatment's effectiveness by allowing for better delivery of the electric field to the tumor. This approach resulted in a reduction of the current needed for treatment and increased the chances of removing the tumor completely. Overall, the use of gel and needle electrodes made the procedure more practical and effective for treating small tumors in dogs.
People also search for: dog skin cancer treatment · electrochemotherapy for dogs · squamous cell carcinoma in dogs · dog tumor treatment options
Abstract
The combination of chemotherapy drugs and high electric field treatment in local cancer is named electrochemotherapy. The European Standard Operation Procedure of Electrochemotherapy (ESOPE) provides guidelines for treatment of cutaneous and subcutaneous tumors. The electrochemotherapy of numerous tumors varying in sizes is more convenient using needle electrodes. However, ESOPE recommends that needle electrodes are applied to deeper tumors. The application of needle electrodes to treatment of superficial small tumors seems to be practical in electrochemotherapy. Plate electrodes and gel improve the electrochemotherapy efficacy. This technique provides electric field homogeneity in irregularly shaped tissue structures (bulk tumors). We propose an investigation of needle electrode and gel in electrochemotherapy of superficial tumors. In vivo experiment with squamous cell carcinoma (SCC) spontaneous nodules in dog was used to validate the mathematical tissue model. The numerical model considers the tissue conductivity dependent on local electric field. Our studies demonstrated that conductive gel is important for effective treatment of superficial tumors with needle electrodes. The needle electrodes and gel presented reduction of medium current, increased the tumor-free margin, and improved the practical application in relation to plate electrode.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26527475/